Ayşe Ceylan HAMAMCIOĞLU, Eylül Gizem KARABAŞ

Yaşlanmada Beyin Sağlığı ve B Vitamini

B vitaminleri suda çözünebilen vitaminler olup, önemli biyolojik rollere sahiptirler. Her B vitamini, anahtar metabolik süreçler için kofaktördür veya gerekli birer öncüdür. Bilişsel işlevler; hafıza, öğrenme, uzamsal yönelim, akıl yürütme, yargılama ve değerlendirmeyi içeren çeşitli beyin fonksiyonlarıdır. Bu işlevlerin azalması, hafif kognitif bozukluk olarak başlayan ve demansa kadar giden ilerleyici bir durumdur. B vitaminlerinin düşük düzeyde alınması sonucu kognitif bozukluk riskinin artması ve yaşlanmaya bağlı hastalıklara katkıda bulunması tek karbon metabolizması ile ilişkilidir. Bu derlemede B vitaminlerini, tek karbon metabolizmasını ve B vitaminlerinin yaşlanmada beyin sağlığı üzerindeki rolünü inceledik.

Brain Health and B Vitamins in Ageing

B vitamins are water-soluble vitamins and have important biological roles. Each B vitamin is a cofactor or essential precursor for key metabolic processes. Cognitive functions are various brain functions that include memory, learning, spatial orientation, reasoning, judgment, and evaluation. The decrease in these functions is a progressive condition that begins as mild cognitive impairment and progresses to dementia. Low intake of B vitamins is associated with a one carbon metabolism, which increases the risk of cognitive impairment and contributes to aging-related diseases. In this review, we examine B vitamins, one carbon metabolism, and the role of B vitamins to aging brain.

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