Sabri Fatih KURŞUNLU, Veli Özgen ÖZTÜRK, Mehmet Zahit BAŞ

YAŞLI BiREYLERDE DiŞETi OLUĞU SIVISI OSTEOKALSiN SEViYESiNiN DEĞERLENDiRiLMESi

AMAÇ: Kemiğin organik yapısında kollagen olmayan proteinlerden biride osteokalsindir. Osteokalsinin periodontal hastalığın patogenezinde rol oynayan bir markır olabileceği sınırlı sayıda çalışmada gösterilmiştir. Bu çalışmada kronik periodontitsli ve periodontal sağlıklı yaşlı bireylerde osteokalsin seviyesinin değerlendirilmesi amaçlanmıştır YÖNTEMLER: Çalışmaya 10’u kronik periodontitisli, 10’u periodontal sağlıklı 65 yaş üstü toplam 20 birey dahil edilmiştir. Örnek alınan bölgelere ait sondalanan cep derinliği, klinik ataşman seviyesi, papil kanama indeksi ve plak indeksi değerleri kaydedildi. Osteokalsin dişeti oluğu seviyesi ELISA yöntemiyle analiz edildi. BULGULAR: Kronik periodontitis grubunda dişeti oluğu sıvısı total miktarı periodontal sağlıklı grubu göre daha az bulunmuştur (p< 0.008). SONUÇ: Çalışma sonuçlarımıza göre osteokalsinin, periodontal hastalıkta anormal kemik yapım-yıkımından sorumlu olabileceğini düşündürmektedir.

Anahtar Kelimeler:

Yaşlılık, periodontit

GINGIVAL CREVICULAR FLUID OSTEOCALCIN LEVELS IN ELDERLY PATIENT WITH PERIODONTAL DISEASE

OBJECTIVE: The aim of this cross-sectional study is to investigate gingival crevicular fluid (GCF) osteocalcin levels in chronic periodontitits (CP) and periodontal healthy in elderly subjects. METHODS: 10 patients with CP alone and 10 healthy elderly patients were enrolled. Probing depth, clinical attachment level, plaque index, and papillary bleeding index were recorded. GCF osteocalcin levels were analyzed by enzyme-linked immunosorbent assay. Parametric tests were used for statistical analysis RESULTS: CP had higher GCF osteocalcin levels compared to healthy groups (P <0.05). CONCLUSION: The present study might suggest that osteocalcin plays a role on periodontal disease pathogenessis. Fluctuating GCF levels of osteocalcin might point out to the abnormal bone turnover in periodontitis.

Keywords:

elderly, periodontitis,

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