Selenyum ve Depresyon Üzerine Etkileri

Sağlığı korumak, hastalığı önlemek ve yaşlanma sürecini yavaşlatmak için yeterli miktarda günlük Selenyum alımı gerekmektedir.Selenyum; redoks homeostazını, tiroid hormon metabolizmasını etkileyen, oksidatif stres ve inflamasyondan koruyan geniş birpleiotropik etki alanına sahip eser elementtir. İnsanlar için hayati öneme sahip olmakla birlikte, doz ve spesifikasyona bağlı olaraktoksik olabilecek bir elementtir. Diğer birçok besinde de olduğu gibi, selenyuma verilen biyolojik yanıtın cinsiyete, selenoproteingenlerindeki nükleotid polimorfizmlerine, bireydeki mevcut Selenyum durumuna, bireyin yaşına ve hastalığın varlığına bağlı olduğudüşünülmelidir. Selenyumun aktif parçacığı selenosisteinlerdir. İnsanlarda selenyumun beslenme kaynaklı fonksiyonlar, selenosisteinbulunduran, selenoproteinler ile sağlanır. Selenoproteinlerin metabolizmadaki rolünün bilinmesi, selenyumun insan sağlığı üzerindekisonuçlarını açıklamaya yardımcı olur. Glutatyon peroksidaz hayvanlardaki çoğu dokuda bulunan ana selenoproteindir. Antioksidansavunma teorileri arasında glutatyon peroksidazlar gibi selenoproteinlerin önemli bir rol oynadığı düşünülmektedir. Selenoproteinlerinbiyosentezi, temel eser element selenyumunun mevcudiyetine bağlıdır. Böylece, selenyumun yeterli alımı, beyin fonksiyonununkorunması için önemlidir. Selenyum eksikliği, kalp ve nöromüsküler bozukluklar dahil olmak üzere birçok patofizyolojik durumu ortaya çıkarabilir. Depresyon için yeterli tedavi seçeneği varken bireylerin önemli bir kısmı hala iyileşme sağlayamamaktadır. Bunedenle, değiştirilebilir risk faktörlerini ve depresyon önleyici etkili yöntemleri araştırmak gerekmektedir. Selenyumun nöroprotektifetkisi henüz kesin olarak tanımlanmamasına rağmen, selenyumun duygu durum bozukluğundaki koruyucu rolü antioksidansavunmadaki önemli etkisiyle ilişkili olabilir. Bu derleme selenyumun depresyon ve diğer depresyon çeşitleri üzerine etkisiniinceleme amacıyla yapılmıştır.

Selenium and Its Effects on Depression

Daily intake of adequate doses is required to maintain health, prevent disease and slow down the aging process. Selenium; redoxhomeostasis, thyroid hormone metabolism, affecting the oxidative stress and inflammation protects the trace element with a wide areaof pleiotropic effect. Selenium is vital for humans, but is a toxic element, depending on dose and specification.6 As with many otherfoods, the biological response to selenium depends on the sex, the nucleotide polymorphisms in the selenoprotein genes, the presentstate of the individual, the age of the individual and the presence of the disease. The active particle of selenium is selenocystein.Nutritional functions of selenium in humans are provided by selenoproteins, including selenocysteine. Knowing the role ofselenoproteins in metabolism helps explain the consequences of selenium on human health. Glutathione peroxidase (Gpx) is the mainselenoprotein found in most tissues in animals. Among the antioxidant defense theories, selenoproteins such as glutathioneperoxidases (GPx) are thought to play an important role. The biosynthesis of selenoproteins depends on the presence of the essentialtrace element selenium. Thus, adequate intake of selenium is important for the preservation of brain function. Selenium deficiencymay reveal many pathophysiological conditions including heart and neuromuscular disorders. While there is sufficient treatment fordepression, a significant number of individuals still do not achieve improvement. Therefore, it is necessary to investigate modifiablerisk factors and methods to prevent depression. Although the neuroprotective effect of selenium has not yet been clearly defined, theprotective role of selenium in mood disorders may be related to the important effect of antioxidant defense. This review wasconducted to investigate the effect of selenium on depression and other types of depression.

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