Muhamed KATICA, Alisa SMAJOVIC, Davorka ZAVRŠNIK, Kenan ČAKLOVICA

Xanten ve Türevlerinin İnsan ve Veteriner Hekimlikte Kullanımı

Ksanten türevleri, doğal, yarı sentetik ve sentetik kökenli olabilen siklik, organik bileşikleri temsil eder. Bu bileşikler, antibakteriyel, antiviral ve antienflamatuar özellikler gibi çeşitli farmakolojik aktiviteler nedeniyle dikkat çekmektedirler. Ayrıca, ilaca dirençli lösemi hatları için ve fotodinamik tedavide antagonistler olarak kullanılmaktadırlar. Ayrıca lazer teknolojisinde boyalar ve biyomoleküllerin görselleştirilmesi için pH'a duyarlı floresan malzemeler olarak uygulanırlar. Veteriner hekimlik alanında yeni hastalıklar nedeniyle, bu bileşiklerin uygulanması çok faydalı olabilir ve literatürde Veteriner araştırma alanındaki benzer bileşiklerin aktivitesi açıklanmaktadır. Bu derlemede ksanten türevlerinin antibakteriyel, antifungal, antihelmintik, antiprotozoal, antikanserojenik ve antidiyabetik aktivite gibi en önemli aktiviteleri ve etki mekanizmaları sunulmuştur.

Application of Xanten and Its Derivatives in Human and Veterinary Medicine

Xanthene derivatives represent cyclic, organic compounds that can be natural, semi-synthetic and synthetic origin.These compounds become very interesting because of various pharmacological activities such as antibacterial, antiviral andanti-inflammatory properties. Furthermore, they have been utilized as antagonists for drug-resistant leukemia lines and inphotodynamic therapy. They are also applied as dyes in laser technology and pH sensitive fluorescent materials forvisualization of biomolecules. Because of new diseases in veterinary medicine, application of these compounds can be veryuseful and literature describes activity of similar compunds in veterinary research field. In this review the most importantactivity of xanthen derivatives such as antibacterial, antifungal, antihelmintic, antiprotozoal, anticancerogenic andantidiabetic activity and mechanism of their action are presented.

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