Mohammad ALHILAL, Suzan ALHILAL, Thana ALBAZ

Altın Suriye Hamsterlarında Hiperlipidemik Diyet ile Oluşturulan Karaciğer Hasarı Üzerine Hodan Yağının Etkileri

Bu çalışma, erkek altın Suriye hamsterinda hiperlipidemik diyet ile oluşturulan karaciğer hasarına karşı Gamma Linolenik Asit (GLA) açısından zengin olan hodan yağının hepatoprotektif etkilerini incelenmek için tasarlanmıştır. Bu deneyde, erkek hamsterden oluşan toplam 60 hayvan kullanılmıştır. Bu deney iki aşamada gerçekleştirilmiştir. İlk aşama 4 hafta sürdü, bu aşamada, hamsterler 4 gruba ayrılmıştır. S1 (kontrol), sadece ticari kemirgen diyeti ile beslenmiştir. Diğer gruplar S2, S3 ve S4 ise 80% ticari kemirgen diyeti +%20 yağ içeren diyet ile beslenmiştir (hiperlipidemik diyet). İkinci aşama da yine 4 hafta sürdü, sadece S2 hiperlipidemik diyetle beslenmiştir. S4’e hodan yağı günlük olarak 2g yağ/kg vücut ağırlığı gavaj yoluyla verilmiştir. Hiperlipidemik diyetin alımı, hepatositlerde lipid birikimine neden oldu ve anlamlı olarak (P

The Effects of Borage Oil on Hyperlipidemic Diet-induced Liver Damage in Male Golden Syrian Hamsters

This study was designed to examine the hepatoprotective effects of Borage seed oil rich in Gamma Linolenic acid(GLA) against hyperlipidemic diet-induced liver damage in the male golden Syrian hamster. In this experiment a total of 60animals of male hamsters were used. This experiment was carried out in 2 periods. The first period lasted 4 weeks, in whichhamsters were segregated into 4 groups. S1 served as control (given a commercial rodent diet only). Other groups, S2, S3 andS4 were fed with a diet containing of %80 commercial rodent diet + 20% fats (Hyperlipidemic Diet). The second period lasted4 weeks, in which S2 only that continued fed with hyperlipidemic diet. S4 was orally gavaged with borage oil at 2 g/kg of thebody weight daily. Hyperlipidemic diet intake caused lipid accumulation in hepatocytes and significantly (P

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