Noradrenalinin İn Vitro Koşullar Altında Besi Hindilerinde İnce ve Kalın Bağırsak Düz Kasları Üzerine Etkisi

Bu çalışmanın amacı heavy hybrid hindilerin ince ve kalın bağırsaklarındaki düz kaslarda bulunan adrenerjik reseptörlerin olası varlığını in vitro koşullar altında farklı konsantrasyonlarda non-selektif adrenerjik reseptör agonisti, noradrenalin, kullanarak belirlemektir. Çalışma 24 besi hindisinde gerçekleştirildi. Organ izolasyon cihazında duodenum, jejunum, ileum, çekum ve kolonun müsküler longitudinal ve sirküler tabakalarında testler farklı konsantrasyonlarda noradrenalin hydrogentartarate solüsyonu kullanılarak test edildi. Çalışma besi hindilerinin ince ve kalın bağırsaklarındaki düz kaslarda bulunan adrenerjik reseptörlerin olası varlığını ortaya koymdu. Noradrenalin’in longitudinal tabaka üzerindeki etkisi, besi hindilerinin ince ve kalın bağırsaklarında ki tunica muscularis sirküler tabaka üzerinde ki etkisinden daha güçlüydü (P

Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions

The aim of the study was to determine the possible presence of adrenergic receptors in the smooth musculature ofsmall and large intestines of heavy hybrid turkey, using different concentrations of non-selective adrenergic receptoragonists, noradrenaline, under in vitro conditions. The research was carried out on 24 fattening turkeys. Tests of circular andlongitudinal layers of muscular duodenum, jejunum, ileum, cecum and colon in the organ isolation apparatus, using differentconcentrations of noradrenaline hydrogentartarate solution, were tested. The research has established the presence ofadrenergic receptors within the smooth musculature of the small and large intestines of fattening turkeys. The effect of thenoradrenaline on the longitudinal layer was stronger (P

___

  • 1. Cupic V., Muminovic M., Kobal S., Velev R., 2014. Textbook of Veterinary Pharmacology. Belgrade, Sarajevo, Ljubljana, Skopje, 2nd edn., p. 291-294, 304-305, National Library of Serbia, Belgrade.
  • 2. Gvozdic D., 2012. Pathophysiology of Endocrinology System. In.: Bozic T., Textbook of Pathophysiology of domestic animals. 2nd edn., p. 394-396, Mladost Biro d.o.o., Belgrade, Serbia.
  • 3. Hodzic A., Hamamdzic M., 2012. Endocrinology of domestic animals. p. 80-97, University textbook, Sarajevo, Bosnia and Herzegovina.
  • 4. Mujezinovic I., 2007. The impact of physiological and pharmacological active substances and their antagonists in the small intestine smooth muscle of broilers. University of Sarajevo, Faculty of Veterinary Medicine, Bosnia and Herzegovina.
  • 5. Guyton AC., Hall JE., 2003. Textbook of Medical Physiology. 10th edn., p. 408-418, Medicinska naklada, Zagreb, Croatia.
  • 6. Bylund DB., Eikenberg DC., Hieble JP., Langer SZ., Lefkowitz RJ., Minneman KP., Molinoff PB., Ruffolo RR., Trendelenburg AU., 1994. IV. International union of pharmacology nomenclature of adrenoceptors. Pharmacol Rev, 46, 121-136.
  • 7. Katica M., Katica A., Mlaco N., 2016. The role of catecholamines in maintenance of homeostasis in digestive tract of domestic animals. Atatürk University Journal of Veterinary Sciences., 11, 106-111.
  • 8. Muminovic M., 1991. The effects of physiological and pharmacological active substances and some of their antagonists in the rumen of cattle in order to improve pharmacotherapy. University of Sarajevo, Faculty of Veterinary Medicine, Bosnia and Herzegovina.
  • 9. Katica M., 2015. Testing the effects of physiologically and pharmacologically active substances and their antagonists in smooth intestine musculature during the turkey fattening phase. University of Sarajevo, Faculty of Veterinary Medicine, Bosnia and Herzegovina.
  • 10. Katica M., 2015. Presence of adrenergic recptors in the wall of caecum during Turkey Fattening Phase. International Congress, One World-One Health-One Vision, Book of Abstracts, p. 113- 115, Sarajevo, Bosnia and Herzegovina.
  • 11. Bylund DB., 2005. Alpha-2 adrenoceptor subtypes: are more better? British J Pharmacol, 144, 159-160.
  • 12. Minitab Inc., 2003. Minitab Statistical Software. Release 14 for Windows, State College, Pennsylvania.
  • 13. MA PM., 1997. Catecholaminergic systems in the zebrafish. III Organization and projection pattern of medullary dopaminergic and noradrenergic neurons. J Comp Neurol, 381, 411-427.
  • 14. Manara L., Croci T., Aureggi G., Guagnini F., MaVrand JP., Le Fur G., Mukenge S., Ferla G., 2000. Functional assessment of adrenoceptor subtypes in huma colonic circular and longitudinal (taenia coli) smooth muscle. Gut, 47, 337-342.
  • 15. De Ponti F., Giaroni C., Cosentino M., Lesshini S., Frigo G., 1996. Adrenergic mechanism in the control of gastrointestinal motility: From basic science to clinical application. Pharmacol Therapeutics, 69, 1, 59-78.
Atatürk Üniversitesi Veteriner Bilimleri Dergisi-Cover
  • ISSN: 1306-6137
  • Yayın Aralığı: Yılda 3 Sayı
  • Yayıncı: Atatürk Üniversitesi Veteriner Fakültesi