Gökhan OTO, Hasan UYAR, Saadet BELHAN, Zübeyir HUYUT, Serkan YILDIRIM, Yavuz Selim SAĞLAM

Kronik Olarak Flor ve 7,12-Dimetilbenzantrasene (DMBA) Maruz Kalmanın Ratlarda Spermatogenezis ve Testisin Histopatolojisine Etkileri

Bu çalışmada, sıçanlarda florür ve polisiklik aromatik hidrokarbon (PAH) türevi olan 7,12-dimetilbenz [a] antrasen(DMBA)'in spermatogenesis ve testisin histopatolojisi üzerine tek tek ve kombinasyon halinde etkilerinin araştırılmasıamaçlandı. 250-300 g ağırlığında 40 erkek Wistar albino sıçanı kullanıldı. Deneyin 90. gününde intrakardiak kan örnekleri vetestis doku örnekleri alındı. Gruplarda ki FSH ve LH düzeylerinde her hangi bir değişiklik gözükmezken testosteron düzeylerininkontrol grubuna göre diğer gruplarda önemli ölçüde düştüğü belirlendi (P

Effects of Chronically Exposure to Flor and 7,12-Dimethylbenzanthracene (DMBA) on Spermatogenesis and Testicular Histopathology in Rats

This study aimed to investigate the effects of both sodium fluoride (NaF) and polycyclic aromatic hydrocarbon (PAH) derivative such as 7,12-dimethylbenz[a]anthracene (DMBA) singly and in combination on spermatogenesis and testis histopathology in rats. Forty male Wistar albino rats weighing 250–300 g used. On the 90th day of the experiment, intracardiac blood samples and testes were taken. While there was no change in FSH and LH levels in the groups, testosterone levels were significantly decreased in the other groups according to the control group (P

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