Ortopedik Enfeksiyonlarda Moleküler Görüntülemenin Rolü

İnflamasyon, immun sistem hücrelerinin doku hasarına karşı yanıtıdır. Enfeksiyon, mikroorganizmaların varlığı ile meydana gelir. Akut ve kronik osteomiyelit, spondilodiskit ve ortopedik implant enfeksiyonları enfeksiyöz hastalıkların heterojen grubudur. Bu hastalıkların ortak yönü klinisyen, radyolog ve nükleer tıp hekimleri tarafından tanı ve tedavisinin yapılmasıdır. Enfeksiyonun erken tanısı ve lokalizasyonu, tedavinin uygun ve erken zamanda yapılabilmesi için önem taşımaktadır. Enfeksiyon sonrası dokuda oluşan patoloji radyolojik yöntemlerle gösterilmektedir. Fakat enfeksiyonun hücresel düzeyde olduğu durumlarda enfeksiyon odağının belirlenmesi açısından nükleer tıp yöntemlerinin önemi büyüktür. Galyum-67 sitrat, Teknesyum-99m (Tc-99m) nanokolloid ve Tc-99m difosfonat türevleri gibi radyofarmasötikler enfeksiyon görüntülemede sık kullanılmaktadır. Bu makalenin,ortopedik enfeksiyonların tanısında moleküler görüntüleme yöntemlerinin öneminin vurgulanmada ve klinik pratikte klinisyenlere yol gösterici olması amaçlanmıştır.

The Role of Molecular Imaging in Orthopedic Infections

Inflammation is the response of immune system cells to tissue damage. Infection is caused by the presence ofmicroorganisms. Acute and chronic osteomyelitis, spondylodiscitis and orthopedic implant infections are aheterogeneous group of infectious diseases. Clinicians, radiologists and nuclear medicine physicians diagnose andtreat them. Early diagnosis and localization of the infection is important for appropriate and early treatment.Pathological processes in tissue after infection is shown with radiological methods. However nuclear medicinemethods have great importance for the determination of the infection focus at the cellular level.Radiopharmaceuticals such as Gallium-67 citrate, Technetium-99m (Tc-99m) nanocolloid and Tc-99mdiphosphonate derivatives are commonly used for infection imaging. This article aims to underline importance ofmolecular imaging methods for diagnosis of orthopedics infections and guidance for clinicians in clinical practice.

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