Mannoz Bağlayıcı Lektin Eksikliği ve Klinik Bulgular

Doğal immünite makrofajlar, doağal öldürücü hücreler, salgısal immünglobulinler ve kompleman sistemi gibi bileşenlerden oluşur. Mannoz bağlayıcı lektin ise opsonizasyon ve kompleman aktivasyonu aracılığı ile doğal immuniteye katkıda bulunmaktadır. Mannoz bağlayıcı lektin eksikliği bazı enfeksiyöz ve otoimmün hastalıklarla ilişkili bulunmuştur. Ancak bazı araştırmalar Mannoz bağlayıcı lektin eksikliğinin doğal immünite için tek başına önemli olmadığını ancak halihazırda mevcut olan bir immün yetersizliğin klinik bozukluklarını artırabileceğini öngörmektedir. Bu yazıda mannoz bağlayıcı lektin ile ilgili klinik çalışmalara ve mannoz bağlayıcı lektin eksikliğinin klinik önemi ele alınmıştır.

Anahtar Kelimeler:

Mannoz bağlayıcı lektin, lektin yolağı, mannoz bağlayıcı lektin eksikliği.

Mannose Binding Lectin Deficiency and Clinical Features

Innate immunity consists of macrophages, neutrophils, natural killer cells, mucosal immunuglobulins and the comlement system. Mannose binding lectin (MBL) takes part in innate immunity through opsonisation and complement activation. MBL deficiency is associated with some infections and autoimmune disorders. However some studies indicate that MBL deficiency alone is not essential for immunity but it may intensify the clinic picture of an immune deficiency that already exists. This article refers to clincal studies related to MBL and brings up the clinical importance of MBL deficiency.

Keywords:

Mannose binding lectin, lectin pathway, mannose binding lectin deficiency.,

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