Subhas BABU, Renita CASTELİNO, Kumuda RAO, Shruthi RAO, Sajad BUCH, Jasmine KAMATH

Human Papillomavirus ve Oral ve Orofarinjeal Karsinomadaki Rolü

İnsan papilloma virüsü (HPV), Papillomaviridae ailesine dahil olan, çift sarmal DNA virüsleri grubundan oluşmaktadır. HPV, skuamöz epitel için afinite gösterir ve cildi veya mukozayı enfekte edebilir. HPV'nin mukozal enfeksiyonu, inokülasyon yaptığı bölgelere göre, anogenital sistem, üretra, deri, larenks, trakeobronşiyal ve oral mukozada ortaya çıkabilir. HPV'nin oral skuamöz hücreli karsinomadaki yüksek frekansına bağlı olarak, bu hastalığın malign potansiyelinde rol oynadığı düşünülmektedir. Bu derleme, HPV enfeksiyonunun olası mekanizmasını, bunun virüsle ilişkili diğer özelliklerle birlikte oral ve orofaringeal karsinomdaki muhtemel rolünü aydınlatmayı amaçlamaktadır

Human Papillomavirus and Its Role in Oral and Oropharyngeal Carcinoma

Human papillomavirus (HPV) consists of a large group of double-stranded DNA viruses, belonging, to the family Papillomaviridae. HPV shows an affinity for squamous epithelium and may infect skin or mucosa. Mucosal infection by HPV may arise in various sites of its inoculation namely, the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa. It has been hypothesized that HPV may have a role in malignant potential of oral squamous cell carcinoma owing to its high frequency. This review aimed at highlighting the possible mechanism of infection of HPV, its possible role in oral and oropharyngeal carcinoma along with other features associated with the virus

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