The relationship of pelvic pain symptoms with CA-125 levels in endometriosis cases

Aim: This study aims to investigate the relationship between CA-125 levels and pelvic pain symptoms in patients with endometriosis.Material and Methods: This study consisted of retrospective data of 31 patients who were admitted to the outpatient clinic ofFaculty of Medicine, Amasya University between 01 January 2013 and 01 January 2018 for complaints of pelvic pain, dysmenorrheaor infertility, who had a preliminary diagnosis of endometriosis by clinical and ultrasonography examination and diagnosedwith endometriosis by laparoscopy or laparotomy as well as 35 patients who received diagnostic laparoscopy for any reason orlaparotomy or laparoscopy for benign or tubal ligation. The study included patients aged 18 to 45 years old. Patient data wererecorded via an information form which included age, presence of infertility, duration of infertility, preoperative CA-125 values,presence of dysmenorrhea and dyspareunia symptoms, previous operation for endometriosis, presence of additional gynecologicalpathology, disease stage, operation notes, primary complaints, preoperative TVS information, gravida, parity, abortion and livingchildren, used medication, if any, chronical diseases, if any.Results: The blood CA-125 levels were statistically significant in the patients considering the presence of chronic pelvic pain,dysmenorrhea and infertility (p < 0.05). Mean CA-125 levels were 51.43 U/ml in patients with chronic pelvic pain symptoms. MeanCA-125 levels were 45.45 (U/ml) in patients with dysmenorrhea. Mean CA-125 was 45.67 (U/ml) in infertile patients and 45.58 (U/ml) in patients with endometriosis. Mean CA-125 levels in patients with additional gynecological diseases were 38.29 (U/ml), whichwas not statistically significant.Conclusion: This study demonstrated that CA-125 levels were significantly associated with pelvic pain symptoms, infertility andendometriosis. In light of the results, preoperative serum CA-125 levels are a predictor and should be considered for patients withchronic pelvic pain.

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