MgSO4 prophylaxis for obstetric reasons: Traditional solutions vs ready-made solutions

MgSO4 prophylaxis for obstetric reasons: Traditional solutions vs ready-made solutions

Aim: Magnesium (Mg) is frequently used in obstetrics as an anticonvulsant and neuroprotection in daily practice. Although readymadesolutions are produced today, health care workers still prepare and use MgSO4 via traditional methods. We planned this studyto investigate the possible benefits of using ready-made solutions.Material and Methods: The solution prepared by traditional methods was compared to a ready-made solution in terms of Mg amount,preparation duration and cost over time.Results: Ready-made solutions resulted in a more homogeneous infusion (386.98±25.30 vs 402.65±21.68), lower cost (6.86 vs 5.56)and less labor loss (1258 (min: 900 – max: 1500) vs 0 sec).Conclusions: This study, it does show that the use of a ready-made solution allows the patient to receive a more homogenousinfusion of magnesium over time, and it is more financially profitable. The use of ready-made MgSO4 solution also prevents the lossof time in the labor force that would have been spent preparing the solution.

___

  • 1. Gupta K, Vohra V, Sood J. The role of magnesium as an adjuvant during general anaesthesia. Anaesthesia 2006;61:1058-63.
  • 2. Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients 2015;7:8199-226.
  • 3. Hilmy MI, Somjen GG. Distribution and tissue uptake of magnesium related to its pharmacological effects. Am J Physiol 1968;214:406-13.
  • 4. Hoane MR. Assessment of cognitive function following magnesium therapy in the traumatically injured brain. Magnes Res 2007;20:229-36.
  • 5. Goni-de-Cerio F, Alvarez A, Lara-Celador I, et al. Magnesium sulfate treatment decreases the initial brain damage alterations produced after perinatal asphyxia in fetal lambs. J Neurosci Res 2012;90:1932-40.
  • 6. Sameshima H, Ikenoue T. Long-term magnesium sulfate treatment as protection against hypoxic-ischemic brain injury in seven-day-old rats. Am J Obstet Gynecol 2001;184:185-90.
  • 7. Esen F, Erdem T, Aktan D, et al. Effects of magnesium administration on brain edema and blood-brain barrier breakdown after experimental traumatic brain injury in rats. J Neurosurg Anesthesiol 2003;15:119-25.
  • 8. Duley L, Gulmezoglu AM, Henderson-Smart DJ, et al. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 2010;CD000025.
  • 9. Nguyen TM, Crowther CA, Wilkinson D, et al. Magnesium sulphate for women at term for neuroprotection of the fetus. Cochrane Database Syst Rev 2013;2:CD009395.
  • 10. Turkish Pharmaceutical Guide website. Available to (15.12.2018): https://www.ilacrehberi.com/v/pre-eklamolmagnezyum- sulfat-40-g1000-ml-iv-infuz-1036b/
  • 11. Thurnau GR, Kemp DB, Jarvis A. Cerebrospinal fluid levels of magnesium in patients with preeclampsia after treatment with intravenous magnesium sulfate: a preliminary report. Am J Obstet Gynecol 1987;157:1435-8.
  • 12. Fong J, Gurewitsch ED, Volpe L, et al. Baseline serum and cerebrospinal fluid magnesium levels in normal pregnancy and preeclampsia. Obstet Gynecol 1995;85:444-8.
  • 13. Apostol A1, Apostol R, Ali E, et al. Cerebral spinal fluid and serum ionized magnesium and calcium levels in preeclamptic women during administration of magnesium sulfate. Fertil Steril 2010;94:276-82.
  • 14. Sevene E, Lewin S, Mariano A, et al. Systems and market failures: the unavailability of magnesium sulphate for the treatment of eclampsia and pre-eclampsia in Mozambique and Zimbabwe. BMJ 2005;331:765-9.
  • 15. Langer A, Villar J, Tell K, et al. Reducing eclampsia-related deaths - a call to action. Lancet 2008;371:705-6. 16. Neilson JP. Magnesium sulphate: the drug of choice in eclampsia. BMJ 1995;311:701-3.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Analysis of metaphors for basic concepts of nursing students

Hava GOKDERE CİNAR

The association between neutrophil to lymphocyte ratio and contrast induced nephropathy in patients with ST segment elevation myocardial infarction

Oktay GÜLCÜ

Initial operative experience with pancreaticoduodenectomy after fellowship training

Servet KARAGÜL, Oktay KARAKOSE, Fikri ARSLAN

Age estimation based on the third molar development in a Turkish population: A radiographic study

Sevgi ÖZCAN, Güldane MAGAT

Assessment of levels of knowledge of breastfeeding counseling of health personnel working in primary health care institutions

Tuba UCAR, Burcu KAYHAN TETİK, Selma FELEK, Semsettin CİTİL, Kemal SENER, Yesim Aksoy DERYA, Ebru İnci COŞKUN

Bacterial colonization in uninfected pilonidal cyst and its role in developing recurrence in postoperative period: Prospective study

Mehmet Akif ÜSTÜNER, Enver İLHAN, Özlem Yüksel ERGİN, Mehmet Tahsin TEKELİ, Uğur GÖKÇELLİ, Hilmi GÜNGÖR, Emine Deniz BAYRAM, Ozcan ALPDOGAN, Orhan ÜREYEN

Comparison of Zwolle, Cadillac and Syntax-2 risk scores in predicting contrast nephropathy development in patients with ST elevation

Kamuran KALKAN

Do inflammation and hormone parameters have effects on IVF results in patients with unexplained infertility?

Pervin KARLI, Ayşe Zehra ÖZDEMİR, Cagri GULUMSER

Is fixation suture necessary in undescended testicle surgery?

Mehmet Emin ÇELİKKAYA, Bülent AKÇORA, Ahmet ATICI

Anatomical and functional results of pars plana vitrectomy+ ILM peeling+ gas endotamponade in patients with idiopathic stage 4 macular hole

İlknur TUNCER FIRAT, Seyhan DİKCİ, Turgut YILMAZ, Soner DEMİREL