Mustafa KARACA, Mustafa Ozay USLU, Arife SABANCI

The effects of diabetes mellitus on peri-implant marginal bone loss in the posterior maxilla

Aim: The aim of this retrospective study was to evaluate the effects of Diabetes Mellitus on peri-implant marginal alveolar bone lossin sinus lifted well-controlled diabetic patients at long term.Materials and Methods: Thirty eight patients with 77 dental implants were included the study. The study consists of 2 groups;control group (C) and diabetes mellitus group (DM). The dental implants were placed after open window maxillary sinus liftingsurgery at maxillary posterior region. After conventional loading process patients were followed periodically for bone loss andclinical parameters. The peri-implant marginal bone loss was assessed at minimum 3 years after functional loading. Standardizedpanoramic radiographs were obtained at the baseline and maintenance which were used for evaluating the marginal bone loss andclinical and anatomical crown to implant ratio. The Student-t test and Mann Whitney-U test were used to analyse any significantdifferences between two groups (p0.05).Conclusion: Within the limitations of this study, it was shown that long-term follow-up results of dental implants in well-controlleddiabetic patients were similar to those of healthy individuals and DM did not increase the peri-implant marginal bone loss.

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1. Wang F, Song YL, Li DH, et al. Type 2 diabetes mellitus impairs bone healing of dental implants in GK rats. Diabetes Res Clin Pract 2010;88:7-9.
2. Abu Hantash RO, Al-Omiri MK, Al-Wahadni AM. Psychological impact on implant patients’ oral health-related quality of life. Clin Oral Implants Res 2006;17:116-23.
3. Fiorellini JP, Nevins ML. Dental implant considerations in the diabetic patient. Periodontol 2000;23:73-7.
4. Morris HF, Winkler S, Ochi S. The ankylos endosseous dental implant: assessment of stability up to 18 months with the Periotest. J Oral Implantol 2000;26:291-9.
5. Krause A, Cowles EA, Gronowicz G. Integrin-mediated signaling in osteoblasts on titanium implant materials. J Biomed Mater Res 2000;52:738-47.
6. Nevins ML, Karimbux NY, Weber HP, et al. Wound healing around endosseous implants in experimental diabetes. Int J Oral Maxillofac Implants 1998;13:620-9.
7. Persson GR, Renvert S. Cluster of bacteria associated with peri-implantitis. Clin Implant Dent Relat Res 2014;16:783- 93.
8. Misch CE. Divisions of available bone in implant dentistry. Int J Oral Implantol 1990;7:9-17.
9. Naert IE, Duyck JA, Hosny MM, et al. Freestanding and toothimplant connected prostheses in the treatment of partially edentulous patients Part II: An up to 15-years radiographic evaluation. Clin Oral Implants Res 2001;12:245-51.
10. Gomez-Polo M, Bartens F, Sala L, et al. The correlation between crown-implant ratios and marginal bone resorption: a preliminary clinical study. Int J Prosthodont 2010;23:33-7.
11. Grossmann Y, Sadan A. The prosthodontic concept of crown-to-root ratio: a review of the literature. J Prosthet Dent 2005;93:559-62.
12. Adell R. Tissue integrated prostheses in clinical dentistry. Int Dent J 1985;35:259-65.
13. Rasmusson L, Meredith N, Sennerby L. Measurements of stability changes of titanium implants with exposed threads subjected to barrier membrane induced bone augmentation. An experimental study in the rabbit tibia. Clin Oral Implants Res 1997;8:316-22.
14. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
15. Sesma N, Garaicoa-Pazmino C, Zanardi PR, et al. Assessment of Marginal Bone Loss around PlatformMatched and Platform-Switched Implants - A Prospective Study. Braz Dent J 2016;27:712-6.
16. Dinato TR, Grossi ML, Teixeira ER, et al. Marginal Bone Loss in Implants Placed in the Maxillary Sinus Grafted With Anorganic Bovine Bone: A Prospective Clinical and Radiographic Study. J Periodontol 2016;87:880-7.
17. Tawil G, Aboujaoude N, Younan R. Influence of prosthetic parameters on the survival and complication rates of short implants. Int J Oral Maxillofac Implants 2006;21:275-82.
18. George K, Zafiropoulos GG, Murat Y, et al. Clinical and microbiological status of osseointegrated implants. J Periodontol 1994;65:766-70.
19. Randow K, Ericsson I, Nilner K, et al. Immediate functional loading of Branemark dental implants. An 18-month clinical follow-up study. Clin Oral Implants Res 1999;10:8-15.
20. Javed F, Romanos GE. Impact of diabetes mellitus and glycemic control on the osseointegration of dental implants: a systematic literature review. J Periodontol 2009;80:1719- 30.
21. McCracken MS, Aponte-Wesson R, Chavali R, et al. Bone associated with implants in diabetic and insulin-treated rats. Clin Oral Implants Res 2006;17:495-500.
22. Balshi TJ, Wolfinger GJ. Dental implants in the diabetic patient: a retrospective study. Implant Dent 1999;8:355-9.
23. Fiorellini JP, Chen PK, Nevins M, et al. A retrospective study of dental implants in diabetic patients. Int J Periodontics Restorative Dent 2000;20:366-73.
24. Farzad P, Andersson L, Nyberg J. Dental implant treatment in diabetic patients. Implant Dent 2002;11:262-7.
25. Abdulwassie H, Dhanrajani PJ. Diabetes mellitus and dental implants: a clinical study. Implant Dent 2002;11:83-6.
26. Sevimay M, Turhan F, Kilicarslan MA, et al. Threedimensional finite element analysis of the effect of different bone quality on stress distribution in an implant-supported crown. J Prosthet Dent 2005;93:227-34.
27. Koca OL, Eskitascioglu G, Usumez A. Three-dimensional finite-element analysis of functional stresses in different bone locations produced by implants placed in the maxillary posterior region of the sinus floor. J Prosthet Dent 2005;93:38-44.
28. Iplikcioglu H, Akca K. Comparative evaluation of the effect of diameter, length and number of implants supporting threeunit fixed partial prostheses on stress distribution in the bone. J Dent 2002;30:41-6.
29. Yokoyama S, Wakabayashi N, Shiota M, et al. The influence of implant location and length on stress distribution for three-unit implant-supported posterior cantilever fixed partial dentures. J Prosthet Dent 2004;91:234-40.
30. Galindo-Moreno P, Fernandez-Jimenez A, O’Valle F, et al. Marginal bone loss in implants placed in grafted maxillary sinus. Clin Implant Dent Relat Res 2015;17:373-83.
31. Albrektsson T, Zarb G, Worthington P, et al. The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants 1986;1:11-25.
32. Moberg LE, Kondell PA, Kullman L, et al. Evaluation of singletooth restorations on ITI dental implants. A prospective study of 29 patients. Clin Oral Implants Res 1999;10:45-53.
33. Wyatt CC, Bryant SR, Avivi-Arber L, et al. A computerassisted measurement technique to assess bone proximal to oral implants on intraoral radiographs. Clin Oral Implants Res 2001;12:225-9.
34. Rangert BR, Sullivan RM, Jemt TM. Load factor control for implants in the posterior partially edentulous segment. Int J Oral Maxillofac Implants 1997;12:360-70.
35. Schneider D, Witt L, Hammerle CHF. Influence of the crownto-implant length ratio on the clinical performance of implants supporting single crown restorations: a crosssectional retrospective 5-year investigation. Clin Oral Implants Res 2012;23:169-74.
36. Malchiodi L, Cucchi A, Ghensi P, et al. Influence of crownimplant ratio on implant success rates and crestal bone levels: a 36-month follow-up prospective study. Clin Oral Implants Res 2014;25:240-51.
37. Birdi H, Schulte J, Kovacs A, et al. Crown-to-implant ratios of short-length implants. J Oral Implantol 2010;36:425-33.
38. Cohen RE. Position paper: periodontal maintenance. J Periodontol 2003;74:1395-401.
39. Quirynen M, De Soete M, van Steenberghe D. Infectious risks for oral implants: a review of the literature. Clin Oral Implants Res 2002;13:1-19.
40. Snauwaert K, Duyck J, van Steenberghe D, et al. Time dependent failure rate and marginal bone loss of implant supported prostheses: a 15-year follow-up study. Clin Oral Investig 2000;4:13-20.