The effect of genetic on dental anxiety: Twin study

The effect of genetic on dental anxiety: Twin study

AbstractAim: Genetic variations contribute differences in defensive behaviors among individuals. However, the exact role of heritability in the etiology of defensive behaviors like dental anxiety is not elucidated clearly. Twin studies provide an excellent source to investigate the relative contribution of genetics and environment in various phenotypic traits or disorders. Therefore, the aim of this study is toexplore the relative contribution of genetics on dental anxiety on Turkish twins by using the classical twin method.Material and Methods: Corah’s Dental Anxiety Scale used for the anxiety measurement of 70 pairs of Turkish twins. Decayed, Missing, Filled-Teeth (DMF-T) index was calculated according to the number of decayed, missing and filled teeth after clinical and radiological examinations.Results: No significant differences and correlations found within the dental anxiety scores of Monozygotic (MZ) and Dizygotic (DZ) twin-pairs. Significant positive correlation for DMF-T scores was found within the MZ and DZ twin-pairs.Conclusion: Based on the data obtained from our study, it can be concluded that environmental factor appears to have a more dominant effect on dental anxiety and the high correlation regarding DMF-T among MZ twin pairs indirectly shows the genetic effect on dental caries.

___

  • 1. Middeldorp CM, Cath DC, Van Dyck R, et al. The comorbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychol Med 2005;35:611-24.
  • 2. Van Houtem CM, Laine ML, Boomsma DI, et al. A review and meta-analysis of the heritability of specific phobia subtypes and corresponding fears. J Anxiety Disord 2013;27:379-88.
  • 3. Lin CS, Wu SY, Yi CA. Association between Anxiety and Pain in Dental Treatment: A Systematic Review and Meta-analysis. J Dent Res 2017;96:153-62.
  • 4. Armfield JM, Heaton LJ. Management of fear and anxiety in the dental clinic: a review. Aust Dent J 2013;58:390-407.
  • 5. Neale MC, Walters EE, Eaves LJ, et al. Genetics of blood-injury fears and phobias: a population-based twin study. Am J Med Genet 1994;54:326-34.
  • 6. Asl AN, Shokravi M, Jamali Z, et al. Barriers and Drawbacks of the Assessment of Dental Fear, Dental Anxiety and Dental Phobia in Children: A Critical Literature Review. J Clin Pediatr Dent 2017;41:399-423.
  • 7. Hettema JM, Neale MC, Kendler KS. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 2001;158:1568-78.
  • 8. Vassend O, Roysamb E, Nielsen CS. Dental anxiety in relation to neuroticism and pain sensitivity. A twin study. J Anxiety Disord 2011;25:302-8.
  • 9. Binkley CJ, Beacham A, Neace W, et al. Genetic variations associated with red hair color and fear of dental pain, anxiety regarding dental care and avoidance of dental care. J Am Dent Assoc 2009;140:896-905.
  • 10. Randall CL, Shaffer JR, McNeil DW, et al. Toward a genetic understanding of dental fear: evidence of heritability. Community Dent Oral Epidemiol 2017;45:66-73.
  • 11. Zinke A, Hannig C, Berth H. Comparing oral health in patients with different levels of dental anxiety. Head Face Med 2018;14:25.
  • 12. Seligman LD, Hovey JD, Chacon K, et al. Dental anxiety: An understudied problem in youth. Clin Psychol Rev 2017;55:25-40.
  • 13. Kaprio J, Sarna S, Koskenvuo M, et al. The Finnish Twin Registry: formation and compilation, questionnaire study, zygosity determination procedures, and research program. Prog Clin Biol Res 1978;24:179-84.
  • 14. Deryakulu D, Caliskan E. A twin study of computer anxiety in Turkish adolescents. Cyberpsychol Behav Soc Netw 2012;15:212-8.
  • 15. Corah NL, Gale EN, Illig SJ. The use of relaxation and distraction to reduce psychological stress during dental procedures. J Am Dent Assoc 1979;98:390-4.
  • 16. Hagglin C, Hakeberg M, Hallstrom T, et al. Dental anxiety in relation to mental health and personality factors. A longitudinal study of middle-aged and elderly women. Eur J Oral Sci 2001;109:27-33.
  • 17. Burt SA. Rethinking environmental contributions to child and adolescent psychopathology: a metaanalysis of shared environmental influences. Psychol Bull 2009;135:608-37.
  • 18. Chen J, Yu J, Li X, et al. Genetic and environmental contributions to anxiety among Chinese children and adolescents--a multi-informant twin study. J Child Psychol Psychiatry 2015;56:586-94.
  • 19. Smoller JW, Paulus MP, Fagerness JA, et al. Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry 2008;65:298- 308.
  • 20. Ray J, Boman UW, Bodin L, et al. Heritability of dental fear. J Dent Res 2010;89:297-301.
  • 21. Oosterink FM, de Jongh A, Hoogstraten J. Prevalence of dental fear and phobia relative to other fear and phobia subtypes. Eur J Oral Sci 2009;117:135-43.
  • 22. Kendler KS, Gardner CO, Annas P, et al. A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome. Arch Gen Psychiatry 2008;65:421-9.
  • 23. Akarslan ZZ, Erten H, Uzun O, et al. Relationship between trait anxiety, dental anxiety and DMFT indexes of Turkish patients attending a dental school clinic. East Mediterr Health J 2010;16:558-62.
  • 24. Yuzugullu B, Gulsahi A, Celik C, et al. Dental anxiety and fear: relationship with oral health behavior in a Turkish population. Int J Prosthodont 2014;27:50-3.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Surgical removal of a self-expanding metallic stent from jejunum in a patient with Roux-en-Y esophagojejunostomy

Kerem KARAMAN, Ozkan SUBASİ, Mehmet AZİRET, Ahmet Tarik EMİNLER, Aydın Seref KOKSAL

Is low back pain asociated with working condition ?

Ulku Figen Demir

Routine hematological parameters do not reflect disease severity and cardiovascular risk in obstructive sleep apnea syndrome

Kadri Murat GURSES, Utku OGAN AKYİLDİZ, Asli AKYOL GURSES

Fifty most cited Turkish Orthopedics and Traumatology articles in international literature: A bibliometric analysis

Mehmet YALCİNOZAN

Monocyte count to high-density lipoprotein cholesterol ratio may be a predictor in ascending aortic aneurysm

Mevlut Serdar KUYUMCU, Yasin OZEN, Mustafa Bilal OZBAY, Aliye KUYUMCU

Importance of flexible bronchoscopy in the diagnosis of childhood respiratory diseases

Haluk COKUGRAS, Ayse AYZİT KİLİNC

Full cup test (FCT) for symptom severity assessment in carpal tunnel syndrome/comparing scores with clinical and neurophysiological findings

Esra Dilek KESKİN, Bahar SAY, Ufuk ERGUN, Hatice AGİR, Gulten KARACA

Atomoxetine induced leukocytosis: A rare presentation

Ali KARAYAGMURLU, Mehmet Zahit SEREFOGLU

The frequency of childhood abuse in bipolar disorder and its impact on the clinical course

Nesrin KARAMUSTAFAALİAGLU, Nesrin TOMRUK, Nihat ALPAY, Serhat CİTAK, Neslihan CANSEL

Bacterial colonization of Intrauterine Device samples from patients without a history of Pelvic Inflammatory Disease

Gorker SEL, Mehmet Ibrahim HARMA