Mevlut Serdar KUYUMCU, Yasin OZEN, Mustafa Bilal OZBAY, Aliye KUYUMCU

Monocyte count to high-density lipoprotein cholesterol ratio may be a predictor in ascending aortic aneurysm

AbstractAim: The predictive value of the monocytes count and HDL-cholesterol ratio (MHR) has been demonstrated in several cardiovascular diseases. Ascending aortic aneurysm (AAA) is an important cause of mortality in adults. The aim of our study was to investigate the relationship between MHR and AAA in patients with hypertension.Material and Methods: 240 consecutive patients with AAA and 240 consecutive patients with normal ascending aortic diameter were recruited into the study by comprehensive transthoracic echocardiography. All data and MHR was compered between two groups.Results: MHR levels were significantly higher in AAA group compared to normal ascending aortic diameter group (p

PDF

___

1. Kuzmik GA, Sang AX, Elefteriades JA. Natural history of thoracic aortic aneurysms. J Vascular Surgery 2012;56:565-71.
2. Gungor B, Ozcan KS, Ozpamuk Karadeniz F, et al. Red cell distribution width is increased in patients with ascending aortic dilatation. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. 2014;42:227-35.
3. Elefteriades JA, Farkas EA. Thoracic Aortic Aneurysm. Clinically Pertinent Controversies and Uncertainties. 2010;55:841-57.
4. Dobrin PB, Baker WH, Gley WC. Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms. Archives of Surgery (Chicago, Ill : 1960). 1984;119:405-9.
5. Demir B, Murat Caglar I, Oktay Tureli H, et al. Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. The Anatolian J Cardiology 2014;14:106-14.
6. Navab M, Reddy ST, Van Lenten BJ, et al. HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nature Reviews Cardiology 2011;8:222-32.
7. Murphy AJ, Woollard KJ, Hoang A, et al. Highdensity lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol 2008;28:2071-7.
8. Biswas SK. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev 2016;2016:5698931.
9. Kanbay M, Solak Y, Unal HU, et al. Monocyte count/ HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. International Urology and Nephrology 2014;46:1619-25.
10. Canpolat U, Cetin EH, Cetin S, et al. Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2016;22:476-82.
11. Cetin EHO, Cetin MS, Canpolat U, et al. Monocyte/ HDL-cholesterol ratio predicts the definite stent thrombosis after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Biomarkers in Med 2015;9:967-77.
12. Tosu AR, Cinar T, Guler A, et al. The usefulness of monocyte to high density lipoprotein cholesterol ratio in prediction for coronary artery ectasia. Turkish J Clinics and Laboratory 2019;10:68-73.
13. Askin L, Cetin M, Turkmen S, et al. The relationship between monocyte/high-density lipoprotein ratio and Selvester QRS score in patients with STEMI. Archives of the Turkish Society of Cardiology 2018;46:260-7.
14. Yayla KG, Canpolat U, Yayla C, t al. A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte/High-Density Lipoprotein Cholesterol Ratio. Acta Cardiologica Sinica 2017;33:41-9.
15. Ruddy JM, Jones JA, Ikonomidis JS. Pathophysiology of Thoracic Aortic Aneurysm (TAA): Is It Not One Uniform Aorta? Role of Embryologic Origin. Progress in Cardiovascular Diseases 2013;56:68-73.
16. Arici M, Birdane A, Guler K, et al. Turkish hypertension consensus report. Archives of the Turkish Society of Cardiology 2015;43:402-9.
17. Altinmakas YS, Yildiz S, Ogus YT, et al. Relationship Between Regional Diastolic Function and Left Ventricular Mass in Essential Hypertension. Archives of the Turkish Society of Cardiology. 2000;28:678-83.
18. Koldaş L, Ayan F, Ilerigelen B, et al.Assessment of Left Ventricular Ejection Fraction by Acoustic Quantification: Comparison with Conventional 2- Dimensional Echocardiography. Archives of the Turkish Society of Cardiology 1996;24:160-3.
19. Elefteriades JA, Farkas EA. Thoracic aortic aneurysm clinically pertinent controversies and uncertainties. J Am Coll Cardiol 2010;55:841-57.
20. Gardin JM, Arnold AM, Polak J, et al. Usefulness of Aortic Root Dimension in Persons ≥65 Years of Age in Predicting Heart Failure, Stroke, Cardiovascular Mortality, All-Cause Mortality and Acute Myocardial Infarction (from the Cardiovascular Health Study). American J Cardiolog. 2006;97:270-5.
21. Baxter BT, Davis VA, Minion DJ, et al.. Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments. Journal of vascular surgery 1994;19:797-802.
22. Grewal N, Franken R, Mulder BJ, et al. Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? Heart Vessels 2016;31:795-806.
23. Cifani N, Proietta M, Tritapepe L, Di Gioia C, Ferri L, Taurino M, et al. Stanford-A acute aortic dissection, inflammation, and metalloproteinases: A review. Annals of Med 2015;47:441-6.
24. Cem O, Yilmaz S, Korkmaz A, et al. Evaluation of the neutrophil-lymphocyte ratio in newly diagnosed nondiabetic hypertensive patients with ascending aortic dilatation. Blood Pressure Monitoring 2016;21:238-43.
25. Han L, Dai L, Zhao YF, et al. Correction: CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function. Aging 2018;10:3627.
26. Ghattas A, Griffiths HR, Devitt A, et al. Monocytes in Coronary Artery Disease and Atherosclerosis: Where Are We Now? Journal of the American College of Cardiology 2013;62:1541-51.
27. Niinimak E, Pynnonen V, Kholova I, et al. Neovascularization with chronic inflammation characterizes ascending aortic dissection. Anatol J Cardiol 2018;20:289-95.
28. Murphy AJ, Woollard KJ. High-density lipoprotein: a potent inhibitor of inflammation. Clinical and Experimental Pharmacology & Physiology. 2010;37:710-8.
29. Yvan-Charvet L, Pagler T, Gautier EL, et al. ATPbinding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science (New York, NY) 2010;328:1689-93.
30. Kuvin JT, Patel AR, Sidhu M, et al. Relation between high-density lipoprotein cholesterol and peripheral vasomotor function. The American J Cardiology. 2003;92:275-9.
31. McCormick ML, Gavrila D, Weintraub NL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology 2007;27:461-9.
32. Herron GS, Unemori E, Wong M, et al. Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms. Arteriosclerosis and thrombosis : A J Vascular Biology 1991;11:1667- 77.
33. Brenneisen P, Briviba K, Wlaschek M, et al. Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fibroblasts. Free Radical Biology & Med 1997;22:515- 24.
34. Gocmen AY, Celikbilek A, Hacioglu G, et al. The relationship between oxidative stress markers and visual evoked potentials in different hypertension models. Anadolu kardiyoloji dergisi : AKD = the Anatolian J Cardiology 2014;14:498-504.
35. Galis ZS, Asanuma K, Godin D, et al. N-acetylcysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: new target for antioxidant therapy? Circulation 1998;97:2445-53.
36. Grote K, Flach I, Luchtefeld M, et al. Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species. Circulation Research 2003;92:80-6.
37. Nicholls SJ, Dusting GJ, Cutri B, et al. Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits. Circulation 2005;111:1543-50.
38. Kunitake ST, Jarvis MR, Hamilton RL, et al. Binding of transition metals by apolipoprotein A-I-containing plasma lipoproteins: inhibition of oxidation of low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America 1992;89:6993-7.
39. Klimov AN, Kozhevnikova KA, Kuzmin AA, et al. On the ability of high density lipoproteins to remove phospholipid peroxidation products from erythrocyte membranes. Biochemistry Biokhimiia 2001;66:300-4.