Serum oxidative stress level correlates with epicardial adipose tissue thickness in heart failure-reduced ejection fraction patients

Serum oxidative stress level correlates with epicardial adipose tissue thickness in heart failure-reduced ejection fraction patients

Aim: In the course of heart failure, various inflammatory cytokines are secreted and oxidative stress occurs. The source of someproduced cytokines is epicardial fat tissue (EFT). There is a positive correlation between EFT thickness and metabolic activity. In thisstudy, we aimed to investigate the relationship between oxidative stress and epicardial fat tissue thickness in patients with heartfailure.Material and Methods: A total of 36 patients with heart failure-reduced ejection fraction as study group and 36 subjects withoutheart failure as control group were included in the study. Biochemical blood analyses and echocardiographic examinations wereperformed.Results: The NT-proBNP level in the heart failure-reduced ejection fraction group was significantly higher than the control group(6506.8±11214.3, 116.5±185.6, respectively, p

___

  • 1. Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart 2007;93:1137-46.
  • 2. Bleumink GS, Knetsch AM, Sturkenboom MCJM, et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J England 2004;25:1614-19.
  • 3. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016 14;37:2129-200.
  • 4. Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiographi 2009;22:1311-19.
  • 5. Eroglu S, Sade LE, Yildirir A, et al. Association of epicardial adipose tissue thickness by echocardiography and hypertension. Turk Kardiyol Dern Ars 2013;41:115-22.
  • 6. Lacobellis G, Bianco AC. Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab 2011;22:450-7.
  • 7. Nakamura K, Kusano K, Nakamura Y, et al. Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation 2002;105:2867-71.
  • 8. Nakamura K, Fushimi K, Kouchi H, et al. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation 1998;98:794-9.
  • 9. Griendling KK, Minieri CA, Ollerenshaw JD, et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994;74:1141-8.
  • 10. Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury. Part II. Animal and human studies. Circulation 2003;108:2034-40.
  • 11. Diaz-Velez CR, Garcia-Castineiras S, Mendoza-Ramos E, at al. Increased malondialdehyde in peripheral blood of patients with congestive heart failure. Am Heart J 1996;131:146-52.
  • 12. Nishiyama Y, Ikeda H, Haramaki N, et al. Oxidative stress is related to exercise intolerance in patients with heart failure. Am. Heart J 1998;135:115-20.
  • 13. Moriyama Y, Yasue H, Yoshimura M, et al. The plasma level of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrin Metab 2000;85:1834-40.
  • 14. Yucel D, Aydogdu S, Senes M, et al. Evidence of increased oxidative stress in patients with dilated cardiomyopathy. Scand. J Clin Lab Invest 2002;62:463-8.
  • 15. Arai M, Alpert NR, MacLennan, et al. Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium. Circulation Research 1993;72:463-9.
  • 16. Hill, MF, & Singal, PK. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. American J Pathology 1996;148:291-300.
  • 17. Iacobellis G, Willens HJ. Echocardiographic epicardial fat: A review of research and clinical applications. J Am Soc Echocardiogr 2009;22:1311-9.
  • 18. Demir B, Demir E, Aciksari G, et al. The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach. Int J Endocrinol 2014;2014:954045.
  • 19. Demir B, Cengiz H, Ungan I, et al. The relationship between epicardial adipose tissue thickness and oxidative stress parameters in patients with isolated polycystic ovary syndrome. Gynecol Endocrinol 2015;31:531-5.
  • 20. Aydogdu A, Karakas EY, Erkus E, et al. Epicardial fat thickness and oxidative stress parameters in patients with subclinical hypothyroidism. Arch Med Sci 2017;13:383-9.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

The rare cause of fever with unknown origin in childhood: Abdominal Tuberculosis

Erdem TOPAL, Hilal KARABAĞ ÇITLAK

Prevalence of anterolateral complex injury and associated injuries in knees with acute complete and partial anterior cruciate ligament injury

Barış POLAT, Tahsin GÜRPINAR, Kaan ERLER, Deniz AYDIN, Mehmet Alp DİRİK, Ayşe Esin POLAT, Ramadan ÖZMANEVRA

Can mean platelet volume (MPV) and platelet/lymphocyte ratio (PLR) be an early predictor for severe acute pancreatitis?

Yasemin GÖKDEN, Orkide KUTLU

Nasofacial and canthal morphometric analysis of Benue Indigenes in central Nigeria

Terkuma CHİA

Structural analysis of the choroid and the optic nerve in diabetes mellitus

Zeynep Eylül ERCAN

An example of a misnomer in medicine: Choice of the term basal ganglia for the basal nuclei

Zafer ŞAHİN, Ömer Faruk KALKAN, Selim KUTLU

Investigation of the characteristics differentiating complicated and non-complicated appendicitis: A prospective analysis

Kasım TURGUT, Sabri ÖZDAŞ, Mehmet ŞİRİK, İrfan AYDIN

Evaluation of clinical results after arthroscopic meniscus repair and partial meniscectomy

Ekrem ÖZDEMİR, Ali CANBAY, Gökay GÖRMELİ, Reşit SEVİMLİ, Yunus OKLU

Evaluation of psychological stress and cortisol levels in males with and without gingivitis

Kübra ARAL, Michael R. MİLWARD, Paul R. COOPER, Özge ÇELİK GÜLER

Our surgical experience in cholangiocellular carcinoma

Uğur TOPAL, Ahmet Gökhan SARITAŞ, Abdullah ÜLKÜ, Kubilay DALCI, Erdi AYDIN, Atılgan Tolga AKÇAM