Reliability of testicular stiffness measurement by shear wave elastography to predict testicular atrophy in patients with chronic liver disease

Reliability of testicular stiffness measurement by shear wave elastography to predict testicular atrophy in patients with chronic liver disease

Aim: Chronic liver disease is one of the most important public health problems in both developed and developing countries. It hasbeen reported that testicular atrophy may occur in these patients. The aim of this study is to demonstrate changes in testicularstructure and elasticity due to hypogonadism secondary to chronic liver disease (CLD) by shear wave elastography (SWE).Material and Methods: Eighteen patients aged 22-50 years were included in the study. The control group consisted of 16 participantsaged 17-52 years. In all patients and in the control group; first scrotal gray scale and doppler US examination were performed todetermine the presence of focal lesions and structural anomalies in both testicles, then the mean testicular shear wave velocityvalues (SWVV) in the parenchyma was calculated. Testicular volumes and testicular arterial flow indices (Vmax, RI) were recorded.Results: The results of 34 participants (patient and control groups) were examined; There was no significant difference betweenvolumetric measurements, flow indices and SWVQ values between the two groups. In addition, right testicular arterial Vmax valueswere lower in the patient group than in the control group (p

___

  • 1. Green GR. Mechanism of hypogonadism in cirrhotic males. Gut. 1977;18:843-53.
  • 2. Sorrell JH, Brown JR. Sexual functioning in patients with endstage liver disease before and after transplantation. Liver Transpl 2006;12:1473-7.
  • 3. Huyghe E, Kamar N, Wagner F, et al. Erectile dysfunction in end-stage liver disease men. J Sex Med 2009;6:1395-401.
  • 4. Cornely CM, Schade RR, Van Thiel DH, et al. Chronic advanced liver disease and impotence: cause and effect? Hepatology. 1984;4:1227-30.
  • 5. Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur J Endocrinol. 2005;152:501- 13.
  • 6. Wiesner RH, McDiarmid SV, Kamath PS, et al. MELD and PELD: application of survival models to liver allocation. Liver Transpl. 2001;7:567-80.
  • 7. Aigner F, De Zordo T, Pallwein-Prettner L, et al. Realtime sonoelastography for the evaluation of testicular lesions. Radiology. 2012;263:584-9.
  • 8. Pallwein-Prettner L, Steiner H, Akkad T, et al. Realtime elastography for evaluation of testicular masses: initial experience. Eur Urol Suppl 2006;5:96.
  • 9. Pastore AL, Palleschi G, Maceroni P, et al. Correlation between semiquantitative sonoelastography and immunohistochemistry in the evaluation of testicular focal lesions. Cancer Imaging 2014 8;14:29.
  • 10. Marsaud A, Durand M, Raffaelli C, et al. Elastography shows promise in testicular cancer detection. Prog Urol 2015;25:75-82.
  • 11. Kantarci F, Cebi Olgun D, Mihmanli I. Shear-wave elastography of segmental infarction of the testis. Korean J Radiol 2012;13:820-2.
  • 12. Patel KV, Huang DY, Sidhu PS. Metachronous bilateral segmental testicular infarction: multi-parametric ultrasound imaging with grey-scale ultrasound, Doppler ultrasound, contrast-enhanced ultrasound (CEUS) and real-time tissue elastography (RTE). J Ultrasound 2014;17:233-8.
  • 13. Sun Z, Xie M, Xiang F, et al. Utility of Real-Time Shear Wave Elastography in the Assessment of Testicular Torsion. PLoS One 2015;10:e0138523
  • 14. Zhang X, Lv F, Tang J. Shear wave elastography (SWE) is reliable method for testicular spermatogenesis evaluation after torsion. Int J Clin Exp Med 2015;8:7089-97.
  • 15. Appelbaum L, Gaitini D, Dogra VS. Scrotal ultrasound in adults. Semin Ultrasound CT MR 2013;34:257-73.
  • 16. Bercoff J, Tanter M, Fink M. Supersonic shear imaging: a new technique for soft tissue elasticity mapping. IEEE Trans Ultrason Ferroelectr Freq Control 2004;51:396-409
  • 17. Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001;122:497- 506
  • 18. Shiraishi K, Natio K. Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on spermatogenesis and expression of p53 protein in male infertility. J Urol 2007;178:1012-7
  • 19. Afsar B. Relationship between total testosterone, cognitive function, depressive behavior, and sleep quality in chronic kidney disease patients not on dialysis. Clin Exp Nephrol. 2013;17:59-65.
  • 20. Cigarrán S, Pousa M, Castro MJ, et al. Endogenous testosterone, muscle strength, and fat-free mass in men with chronic kidney disease. J Ren Nutr 2013;23:e89-95.
  • 21. Yilmaz MI, Sonmez A, Qureshi AR, et al. Endogenous testosterone, endothelial dysfunction, and cardiovascular events in men with nondialysis chronic kidney disease. Clin J Am Soc Nephrol 2011;6:1617- 25
  • 22. Haring R, Nauck M, Völzke H, et al. Low serum testos¬terone is associated with increased mortality in men with stage 3 or greater nephropathy. Am J Nephrol 2011;33:209-17
  • 23. Hamdan A, Abdulla A, Yousef M. Evaluation of tes¬ticular disease using ultrasound. IJSR 2013;2:12- 9.
  • 24. Schurich M, Aigner F, Frauscher F, et al. The role of ultrasound in assessment of male fertility. Eur J Obstet Gynecol Reprod Biol 2009;144:192-8.
  • 25. McLaughlin J, Renzi D. Shear wave speed recovery in tran¬sient elastography and supersonic imaging using propagat¬ing fronts. Inverse Probl 2006;22:681-706.
  • 26. Aigner F, De Zordo T, Pallwein-Prettner L, et al. Realtime sonoelastography for the evaluation of testicular lesions. Radiology 2012;263:584-9.
  • 27. Sakamoto H, Ogowa Y, Yoshida H. Relationship between testicular volume and testicular function: comparison of the Prader orchidometric and ultra¬sonographic measurements in patients with infertility. Asian J Androl 2008;10:319-24.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi