Radiological evaluation of anatomical changes in implant and adjacent segments after rigid fusion

Radiological evaluation of anatomical changes in implant and adjacent segments after rigid fusion

Aim: We aimed to determine the anatomical remodeling seen after lumbar spine stabilization in detail. Using magnetic resonanceimages, it is also aimed to reveal this remodeling is not only limited to the adjacent segment and also happens in the upperinstrumented vertebra region. At the end of this study, it is suggested to develop new radiological parameters to predict the changesin the adjacent segment and upper instrumented vertebra regions.Materials and Methods: Twenty cases operated for degenerative lumbar stenosis were included in our study. Quantitative datawere obtained by radiological measurements by a radiologist and neurosurgeon. On magnetic resonance images, the anatomicalstructures changed by remodeling were compared before and after the operation during (6-26 months) postoperative period. Unlikeprevious studies, anterior, middle and posterior disc heights; Cobb angle in the adjacent segment, spinal canal area, bilateral neuralforamen, facet joint areas and flavum thicknesses were evaluated.Results: From the sixth month after lumbar fusion, it was observed that angles and anatomical structures were changed in adjacentsegment. Also, it was observed that the areas with neural structures expanded in the upper instrumented vertebra region. Thedegeneration in adjacent segment and relaxation in the upper instrumented vertebra region were found to be statistically significant.A statistically strong positive correlation was found between the number of vertebrae included in the lumbar fusion and the meanheight of the adjacent segment disc (r: 0.526, p: 0.017).Conclusion: After comparing the measurements in adjacent segment and upper instrumented vertebra regions before and after theoperation, it was concluded that the remodeling was statistically significant. We suggest that the parameters in our study can beused as a scoring method for early detection of adjacent segment degeneration and/or disease. Thus, it will be possible to createfollow-up indicators findings after fusion.

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  • 1. Ozger O, Kaplan N. Evaluation of clinical outcomes of 271 patients undergoing lumbar microdiscectomy in the light of literature. Ann Med Res 2020;27:664-9.
  • 2. Hilibrand AS, Robbins M. Adjacent segment degeneration and adjacent segment disease : the consequences of spinal fusion? Spine J 2004;4:190-4.
  • 3. Martin BI, Mirza ÃSK, Spina N, et al. Trends in Lumbar Fusion Procedure Rates and Diseases in the United States , 2004 to 2015. Spine (Phila Pa 1976) 2019;44:369-76.
  • 4. Babayev R, Özgen S, Ekşi M, et al. Lomber Posterior Transpediküler Fiksasyon ile Füzyon Operasyonu Yapılan Hastalarda Postoperatif Dönemde Gelişen Komşu Segment Dejenerasyonu ve klinik Sonuçları. Türk Nöroşir Derg 2015;25:22-6.
  • 5. Park P, Garton HJ, Gala VC, et al. Adjacent segment disease after lumbar or lumbosacral fusion: Review of the literature. Spine (Phila Pa 1976) 2004;29:1938-44.
  • 6. Masevnin S, Ptashnikov D, Michaylov D, et al. Risk factors for adjacent segment disease development after lumbar fusion. Asian Spine J 2015;9:239-44.
  • 7. Kim HJ, Kang KT, Son J, et al. The influence of facet joint orientation and tropism on the stress at the adjacent segment after lumbar fusion surgery: A biomechanical analysis. Spine J 2015;15:1841-7.
  • 8. Kotani Y, Cunningham BW, Cappuccino A, et al. The effects of spinal fixation and destabilization on the biomechanical and histologic properties of spinal ligaments: An in vivo study. Spine (Phila Pa 1976) 1998;23:672-83.
  • 9. Ohtori S, Orita S, Yamauchi K, et al. Change of lumbar ligamentum flavum after indirect decompression using anterior lumbar interbody fusion. Asian Spine J 2017;11:105-12.
  • 10. Otsuka Y, An HS, Ochia RS, et al. In Vivo Measurement of Lumbar Facet Joint Area in Asymptomatic and Chronic Low Back Pain Subjects. Spine (Phila Pa 1976) 2010;15:924-8.
  • 11. Yoshiiwa T, Miyazaki M, Notani N, et al. Analysis of the relationship between ligamentum flavum thickening and lumbar segmental instability, disc degeneration, and facet joint osteoarthritis in lumbar spinal stenosis. Asian Spine J 2016;10:1132-40.
  • 12. Hashimoto K, Aizawa T, Kanno H, et al. Adjacent segment degeneration after fusion spinal surgery—a systematic review. Int Orthop 2019;43:987-93.
  • 13. Okuda S, Yamashita T. Adjacent Segment Disease After Posterior Lumbar Interbody Fusion : A Case Series of 1000 Patients. Glob Spine J 2018;8:722-7.
  • 14. Hong CH, Park JS, Jung KJ, et al. Measurement of the Normal Lumbar Intervertebral Disc Space Using Magnetic Resonance Imaging. Asian Spine J 2010;4:1-6.
  • 15. Tunset A, Kjaer P, Chreiteh SS, et al. A method for quantitative measurement of lumbar intervertebral disc structures : an intra- and inter-rater agreement and reliability study. Chiropr Man Therap 2013;21:26.
  • 16. Hamid RS, Akhtar W, Shamim MS, et al. Original Article Observer variation in MRI evaluation of patients with suspected lumbar disc herniation and nerve root compression : Comparison of Neuroradiologist and Neurosurgeon ’ s interpretations. J Pak Med Assoc 2012;62:826-9.
  • 17. Horng MH, Kuok CP, Fu MJ, et al. Cobb angle measurement of spine from x-ray images using convolutional neural network. Comput Math Methods Med 2019;2019: 6357171.
  • 18. Lim YS, Mun JU, Seo MS, et al. Dural sac area is a more sensitive parameter for evaluating lumbar spinal stenosis than spinal canal area: A retrospective study. Med (United States) 2017;96:19-21.
  • 19. Jain P KM. Prediction of biomechanical behavior of lumbar vertebrae using a novel semi-rigid stabilization device. Proc Inst Mech Eng H 2019;233:849-57.
  • 20. Otani K, Kikuchi S, Yabuki S, et al. Lumbar Spinal Stenosis Has a Negative Impact on Quality of Life Compared with Other Comorbidities : An Epidemiological Cross-Sectional Study of 1862 Community-Dwelling Individuals. ScientificWorldJournal 2013;2013:1-9.
  • 21. Cristofolini L, Brandolini N, Danesi V, et al. Strain distribution in the lumbar vertebrae under different loading configurations. Spine J 2013;13:1281-92.
  • 22. Glattes RC, Bridwell KH, Lenke LG, et al. Proximal Junctional Kyphosis in Adult Spinal Deformity Following Long Instrumented Posterior Spinal Fusion Incidence , Outcomes , and Risk Factor Analysis 2005;30:1643-9.
  • 23. Kreiner DS, Shaffer WO, Baisden JL, et al. An evidencebased clinical guideline for the diagnosis and treatment of degenerative lumbar spinal stenosis ( update ). Spine J 2013;13:734-43.
  • 24. Watters WC, Baisden J, Gilbert TJ, et al. Degenerative lumbar spinal stenosis : an evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spinal stenosis. Spine J 2008;8:305-10.
  • 25. Lange T, Schulte TL, Gosheger G, et al. Effects of multilevel posterior ligament dissection after spinal instrumentation on adjacent segment biomechanics as a potential risk factor for proximal junctional kyphosis: A biomechanical study. BMC Musculoskelet Disord 2018;19:4-11.
  • 26. Natarajan RN, Andersson GBJ. Lumbar disc degeneration is an equally important risk factor as lumbar fusion for causing adjacent segment disc disease. J Orthop Res 2017;35:123-30.
  • 27. Bruno AG, Anderson DE, D’Agostino J BM. The effect of thoracic kyphosis and sagittal plane alignment on vertebral compressive loading. J Bone Min Res 2012;27:2144-51.
  • 28. Huang YP, Du CF, Cheng CK, et al. Preserving posterior complex can prevent adjacent segment disease following posterior lumbar interbody fusion surgeries: A finite element analysis. PLoS One 2016;11:1-13.
  • 29. Ma Z, Huang S, Sun J, et al. Risk factors for upper adjacent segment degeneration after multi-level posterior lumbar spinal fusion surgery. J Orthop Surg Res 2019;14:1-7.
  • 30. Broberg K. On the mechanical behaviour of intervertebral discs. Spine (Phila Pa 1976) 1983;8:151- 65.
  • 31. Moore RJ. The vertebral endplate: Disc degeneration, disc regeneration. Eur Spine J 2006;15:333-7.
  • 32. Anandjiwala J, Seo JY, Ha KY, et al. Adjacent segment degeneration after instrumented posterolateral lumbar fusion: A prospective cohort study with a minimum five-year follow-up. Eur Spine J 2011;20:1951-60.
  • 33. Sterba M, Aubin C-éric, Wagnac E, et al. Effect of impact velocity and ligament mechanical properties on lumbar spine injuries in posterior-anterior impact loading conditions : a finite element study. Med Biol Eng Comput 2019;57:1381-92.
  • 34. Rohlmann A, Boustani HN, Bergmann G, et al. Effect of a pedicle-screw-based motion preservation system on lumbar spine biomechanics : A probabilistic finite element study with subsequent sensitivity analysis. J Biomech 2010;43:2963-9.
  • 35. Throckmorton TW, Hilibrand AS, Mencio GA, et al. The Impact of Adjacent Level Disc Degeneration on Health Status Outcomes Following Lumbar Fusion. Spine (Phila Pa 1976) 2003;28:2546-50.
  • 36. Bredow J, Löhrer L, Oppermann J, et al. Pathoanatomic Risk Factors for Instability and Adjacent Segment Disease in Lumbar Spine: How to Use Topping Off? Biomed Res Int 2017;2017: 2964529.
  • 37. Bushell GR, Ghosh DP, Taylor TK, et al. The effect of spinal fusion on the collagen and proteoglycans of the canine intervertebral disc. J Surg Res 1978;25:61-9.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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