Hemolytic disease of the newborn due to minor blood group incompatibility: Sibling cases

Hemolytic disease of the newborn due to minor blood group incompatibility: Sibling cases

Hemolytic disease of the newborn is mostly caused by the hemolysis of fetal erythrocytes by maternal and placental antibodies.Antigens in this group are Kell, Duffy, Kidd, MNSs and the E, e, C, c found in the Rh system. They are responsible for 3-5% of hemolyticdisease of the newborn. In cases of minor blood group incompatibility, clinical picture may vary from subclinical hemolysis findingsto active hemolysis and from blood clotting to neonatal jaundice. Here we present two sibling cases with multiple minor blood group(c, Kell, Cw) incompatibilities of whom the first one was diagnosed two years ago as glucose 6-phosphate dehydrogenase deficiencyand undergone exchange transfusion and ultimately diagnosed as minor blood group incompatibility after the diagnosis of thesecond sibling.

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  • 2. Moise KJ. Fetal anemia due to non-Rhesus-D redcell alloimmunization. Semin Fetal Neonatal Med 2008;13:207-14.
  • 3. Orgun A, Çalkavur Ş, Olukman Ö, et al. Role of minor erythrocyte antigens on alloimmunızation in neonatal indirect hyperbilirubinemia background. Turk Arch Ped 2013;48:23-9.
  • 4. Karagol BS, Zenciroglu A, Okumus N, et al. Hemolytic disease of the newborn caused by irregular blood subgroup (Kell, C, c, E, and e) incompatibilities: report of 106 cases at a tertiary-care centre. Am J Perinatol 2012;29:449-54.
  • 5. Farnault L, Garcia-Meric P, Cortey A, et al. Fetomaternal antiRH3,-4 (anti-E and anti-c) rhesus isoimmunization: A case report. Arch Pediatr 2011;18:176-82.
  • 6. Markham KB, Rossi KQ, Nagaraja HN, O’Shaughnessy RW. Hemolytic disease of the fetus and newborn due to multiple maternal antibodies. Am J Obstet Gynecol 2015;213:68.1-5.
  • 7. Ozkaya H, Karademir F, Suleymanoğlu S, ve ark. Yenidoğanın anti-E antikoruna bağlı hemolitik hastalığı-olgu sunumu. Nobel Med 2006;2:24-6.
  • 8. Erdeve O, Okulu E, Olukman O, et al. The Turkish Neonatal Jaundice Online Registry: A national root cause analysis. PLoS One 2018;23;13:0193108.
  • 9. Dajak S, Culic S, Stefanovic V, et al. Relationship between previous maternal transfusions and haemolytic disease of the fetus and newborn mediated by non-RhD antibodies. Blood Transfus 2013;11:528- 32.
  • 10. Celik HT, Günbey C, Unal S, et al. Glucose-6- phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe experıence. J Paediatr Child Health 2013;49:399-402.
  • 11. Zwiers C, Scheffer-Rath MEA, Lopriore E, et al. Immunoglobulin for alloimmune hemolytic disease in neonates (Review). Cochrane Database Syst Rev 2018 Mar 18;3:CD003313.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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