Effect of vitamin D levels on lipid, glucose, vitamin B12 andC-reactive protein in acute ischemic stroke
Effect of vitamin D levels on lipid, glucose, vitamin B12 andC-reactive protein in acute ischemic stroke
Aim: Stroke ranks second among the causes of death world wideand related disability and death rates are high. Recent studies haveshown that vitamin D deficiency is higher in patients with ischemic stroke compared to other patients and vitamin D deficiency has emerged as a new risk factor. The aims of the study are to investigate the relation between levels of vitamin D in patients diagnosed with acute ischemic stroke with levels of vitamin B12, glucose, HbA1c, blood urea nitrogen (BUN), creatinine, C-reactive protein (CRP)and lipids, and to determine the effect of vitamin D deficiency on other factors that increase the risk of acute ischemic stroke.Materials and Methods: Two thousand seven hundred thirty-four patients diagnosed with acute ischemic stroke were included in thestudy. Results of laboratory tests for levels of vitamin D, vitamin B12, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides,glucose, HbA1c, BUN, creatinine and CRP were recorded.Results: As for correlation between vitamin D and other parameters, positive correlations between vitamin D and age, vitamin B12,BUN and creatinine, and negative correlations between vitamin D and triglycerides, LDL cholesterol, VLDL cholesterol, glucose, HbA1c and CRP were identified. Vitamin D and HDL cholesterol showed no correlation in normal HDL values, but there was positive correlation in patients with HDL cholesterol levels
___
- 1. Fidan F, Alkan BM, Tosun A. Pandemic Era: Vitamin D Deficiency and Insufficiency. Turkish J Osteoporosis
- 2014;20:71-4,
- 2. Avci M Kozaci N, Atik I, et al. Analysis of acute stroke
- patients admitted to the emergency department. Ann
- Med Res 2018;25:406-9.
- 3. Ucar F, Taslipinar MY, Soydaş AO, et al. 25-OH Vitamin D Levels in Patients Admitted to Ankara Etlik İhtisas
- Training and Research Hospital.Eur J Basic Med Sci
- 2012;2:12-5.
- 4. Narasimhan S, Balasubramanian P. Role of Vitamin
- D in the Outcome of Ischemic Stroke- A Randomized
- Controlled Trial. J Clin Diagn Res 2017;11:6-10.
- 5. Wei ZN, Kuang JG. Vitamin D deficiency in relation
- to the poor functional outcomes in nondiabetic
- patients with ischemic stroke Biosci Rep 2018;38
- BSR20171509
- 6. Turetsky A, Goddeau RP Jr, Henninger N. Vitamin
- D independently predicts cerebral infarct volume
- and post-stroke outcome. J Stroke Cerebrovasc
- 2015;24:1555-63.
- 7. Berghout BP, Fani L, Heshmatollah A, et al. Vitamin
- D Status and Risk of Stroke: The Rotterdam Study.
- Stroke 2019;50:2293-8.
- 8. Moretti R, Morelli ME, Caruso P. Vitamin D in
- Neurological Diseases: A Rationale for a Pathogenic
- Impact. Int J Mol Sci 2018;19:2245.
- 9. Wu C, Qiu S, Zhu X, et al. Vitamin D supplementation and glycemic control in type 2 diabetes patients:
- A systematic review and meta-analysis. Metab
- 2017;73:67-76.
- 10. Xu T, Zhong C, Peng Y, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcome amongst acute
- ischaemic stroke patients with low high density
- lipoprotein cholesterol. Eur J Neurol 2016;23:1763-8.
- 11. Schwetz V, Scharnagl H, Trummer C, et al. Vitamin
- D supplementation and lipoprotein metabolism: A
- randomized controlled trial. J Clin Lipidol 2018;12:588-
- 96.
- 12. Ahangar AA. Predictive ability of C-reactive protein for
- stroke. Caspian J Intern Med 2016;7:151-2.
- 13. Kitagawa K, Hosomi N, Nagai Y, et al. Cumulative
- Effects of LDL Cholesterol and CRP Levels on
- Recurrent Stroke and TIA. J Atheroscler Thromb
- 2019;26:432-41.
- 14. Danielsson C, Nayeri S, Wiesinger H, et al. Potent gene
- regulatory and antiproliferative activities of 20-methyl
- analogues of 1,25dihydroxyvitamin D3. J Cell Biochem
- 1996;63:199-206.
- 15. Boonstra A, Barrat FJ, Crain C, et al. 1alpha,25-
- Dihydroxyvitamin d3 has a direct effect on naive
- CD4(+) T cells to enhance the development of Th2
- cells. J Immunol 2001;167:4974-80.
- 16. Jablonski KL, Chonchol M, Pierce GL, et al.
- 25-Hydroxyvitamin D deficiency is associated with
- inflammation-linked vascular endothelial dysfunction
- in middle-aged and older adults. Hypertension,
- 2011;57:63-9.
- 17. Cirillo P, Golino P, Calabrò P, et al. C-reactive protein
- induces tissue factor expression and promotes
- smooth muscle and endothelial cell proliferation.
- Cardiovasc Res. 2005;68:47-55.
- 18. Wang Q, Zhu Z, Liu Y, et al. Relationship between serum vitamin D levels and inflammatory markers in
- acute stroke patients. Brain Behav 2018;8:e00885.
- 19. Weikert C, Dierkes J, Hoffmann K, et al. B vitamin
- plasma levels and the risk of ischemic stroke and
- transient ischemic attack in a German cohort. Stroke.
- 2007;38:2912-8.
- 20. Markišić M, Pavlović AM, Pavlović DM. The Impact of
- Homocysteine, Vitamin B12, and Vitamin D Levels on
- Functional Outcome after First Ever Ischaemic Stroke.
- Biomed Res Int. 2017;2017:5489057.
- 21. Esnafoglu E, Yaman E. Vitamin B12, folic acid,
- homocysteine and vitamin D levels in children and
- adolescents with obsessive compulsive disorder.
- Psychiatry Res 2017;254:232-7.
- 22. Aktas S. Vitamin B12 And Vitamin D Levels In
- Patients with Autoimmune Hypothyroidism And
- Their Correlation With The Antithyroid Peroxidase
- Antibodies. Med Prin Pract 2019.
- 23. Visconti L, Benvenga S, Lacquaniti A, et al. Lipid
- disorders in patients with renal failure: Role in
- cardiovascular events and progression of chronic
- kidney disease. J Clin Transl Endocrinol. 2016;6:8-14.
- 24. Echida Y, Mochizuki T, Uchida K, et al. Risk factors for
- vitamin D deficiency in patients with chronic kidney
- disease. Intern Med 2012;51:845-50.
- 25. Rodríguez VI, Ortega O, Gallar P, et al. Clinical and
- biochemical characteristics of predialysis patients
- in terms of 25 hydroxy vitamin D levels]. Nefrologia
- 2011;31:185-91.