Ebru Celik, Hasan Ikbal Atilgan, Hulya Yalcin, Zeynel Onder, Yusuf Celik

Relationship between Helicobacter Pylori and Parapsoriasis

Aim: Parapsoriasis is a rare skin disorder characterized by erythematous, squamous, atrophic patchy lesions. Its etiopathogenesis and trigger factors still remain unclear. Parapsoriasis cases carry an increased risk of transformation into cutaneous T cell lymphoma. In the literature, there is no data about Helicobacter pylori ( H. pylori) frequency in parapsoriasis. This study aims to evaluate the relationship between H. pylori infection and parapsoriasis. Materials and Methods: The study included thirty patients with parapsoriasis who had no dispeptic complaint and thirty healthy individuals. The patient group was divided into two groups as patients with small plaque parapsoriasis (SPP) and those with large plaque parapsoriasis (LPP) based on clinical examination. Carbon 14 urea breath test was performed to evaluate presence of H. pylori in both patient and control groups. Results: Parapsoriasis cases had a significantly higher rate (18/30, 60.0%) of H. pylori positivity than controls (9/30, 30.0%) (p=0.020). Whereas patients with SPP and patients with LPP had similar rates of H. pylori positivity (55.6% vs 44.4%, p=0.279). Comparison of H. pylori status according to gender it was found that majority of H. pylori positive individuals were men, indicating a significant difference (p=0.014). Conclusion: Our results revealed that H. pylori infection is increased in patients with parapsoriasis. Therefore, it was thought that H. pylori may be associated with parapsoriasis and this agent may play a role in the etiopathogenesis of the disease

PDF

___

1. Das S. Parapsoriasis. http://www.merckmanuals. com/professional/dermatologic-disorders/psoriasis- and-scaling-diseases/parapsoriasis accessed date Apr 30, 2020.
2. Sarveswari KN, Yesudian P. The conundrum of parapsoriasis versus patch stage of mycosis fungoides. Indian J Dermatol Venereol Leprol 2009;75:229-35.
3. Tsang KW, Lam SK. Extragastroduodenal conditions associated with Helicobacter pylori infection. Hong Kong Med J 1999;5:169-74.
4. Shiotani A, Okada K, Yanaoka K, et al. Beneficial effect of Helicobacter pylori eradication in dermatological diseases. Helicobacter 2001;6:60-5.
5. Pakodi F, Abdel-Salam OME, Debreceni A, et al. Helicobacter pylori. One bacterium and a broad spectrum of human disease! An overview. J Physiol 2000;94:139-52.
6. Wedi B, Kapp A. Helicobacter pylori infection in skin diseases: a critical appraisal. Am J Clin Dermatol 2002;3:273-82.
7. Mogaddam MR, Yazdanbod A, Ardabili NS, et al. Relationship between Helicobacter pylori and idiopathic chronic urticaria: effectiveness of Helicobacter pylori eradication. Postepy Dermatol Alergol 2015;32:15-20.
8. Cınar A, Sadıc M, Atılgan HI, et al. Prevalence of Helicobacter pylori infection in school and pre-school aged children with C-14 urea breath test and the association with familial and envorimental factors. Mol Imaging Radionucl Ther 2015;24:66-70.
9. Veldhuyzen van Zanten SJ, Tytgat KM, Hollingsworth J, et al. 14C-urea breath test for the detection of Helicobacter pylori. Am J Gastroenterol 1990;85:399- 403.
10. Bulut M. Mycosis fungoides hastalarında Helicobacter pylori prevalansı ve etyolojideki rolü. http://www. istanbulsaglik.gov.tr/w/tez/pdf/deri_zuhrevi/dr_ murat_bulut.pdf accessed date Apr 30, 2020.
11. McGirt LY. Parapsoriasis (small plaque and large plaque parapsoriasis). https://www.uptodate.com/ contents/parapsoriasis-small-plaque-and-large- plaque-parapsoriasis?search=parapsoriasis&so urce=search result&selectedTitle=1~10&usage type=default&display rank=1 Updated 2018. accessed date Apr 16, 2020.
12. Fischbach W, Malfertheiner P, Hoffman JC, et al. Helicobacter pylori and gastroduodenal ulcer disease. Dtsch Arztebl Int 2009;106:801–8.
13. Hernando-Harder AC, Booken N, Goerdt S, et al. Helicobacter pylori infection and dermatologic diseases. Eur J Dermatol 2009;19:431-44.
14. Shabrawy RM, Gharib K. Helicobacter pylori infection as a risk factor in patients suffering from food allegy and urticaria. Egypt J Immunol 2016;23:67-75.
15. Yang X. Relationship between Helicobacter pylori and Rosacea: review and discussion. BMC Infect Dis 2018;18:318.
16. Mesquita PM, Diogo A Filho, Jorge MT, et al. Relationship of Helicobacter pylori seroprevalence with the occurrence and severity of psoriasis. An Bras Dermatol 2017;92:52-7.
17. Yong WC, Upala S, Sanguankeo A. Association between Psoriasis and Helicobacter pylori Infection: A Systematic Review and Meta-analysis. Indian J Dermatol 2018;63:193-200.
18. Onsun N, Arda Ulusal H, Su O, et al. Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. Eur J Dermatol 2012;22:117-20.
19. Visy B, Füst G, Bygum A, et al. Helicobacter pylori infection as a triggering factor of attacks in patients with hereditary angioedema. Helicobacter 2007;12:251-7.
20. Rifaioglu EN, Aydogan F, Bulbul Sen B, et al. Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo. Turk J Med Sci 2014;44:1051-4.
21. Ersoy O, Ersoy R, Yarar O, et al. H pylori infection in patients with Behçet's disease. World J Gastroenterol 2007;13:2983-5.
22. Van Krieken JH, Hoeve MA. Epidemiological and prognostic aspects of gastric MALT-lymphoma. Recent Results Cancer Res 2000;156:3-8.
23. Kuo SH, Wu MS, Yeh KH, et al. Novel insights of lymphomagenesis of Helicobacter pylori-dependent gastric mucosa-associated lymphoid tissue lymphoma. Cancers (Basel) 2019;11:547.
24. D'Elios MM, Amedei A, Del Prete G. Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low- grade mucosa-associated lymphoid tissue (MALT) lymphoma. Microbes Infect 2003;5:723-30.
25. Capitani N, Codolo G, Vallese F, et al. The lipoprotein HP1454 of Helicobacter pylori regulates T-cell response by shaping T-cell receptor signalling. Cell Microbiol 2019;21:e13006.
26. Ohmatsu H, Saeki H, Fujita H, et al. Mycosis fungoides associated with intestinal mucosa- associated lymphoid tissue lymphoma. Int J Dermatol 2005;44:878-80.
27. Latkowski JA, Heald P. Cutaneous T cell lymphomas. In: Freedberg IM, Eisen AZ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. Vol 2, 6th ed. New York: Mc Graw Hill; 2003;1537-58.
28. Kim-James HY, Heffernan MP. The diagnosis, evaluation, and treatment of cutaneous T-cell lymphoma. Curr Probl Dermatol 2001;13:301-40.
29. Daye M, Mevlitoglu I, Sahin TK, et al. Is Helicobacter pylori infection a risk factor for Mycosis Fungoides? Genel Tıp Derg 2013;23:77-80.
30. Hong W, Tang HL, Dong XL, et al. Prevalence of Helicobacter pylori infection in a third-tier Chinese city: relationship with gender, age, birth-year and survey years. Microb Health Dis 2019;1:e150.