Kamuran KALKAN

Comparison of Zwolle, Cadillac and Syntax-2 risk scores in predicting contrast nephropathy development in patients with ST elevation

Aim: It is known that early prediction of the patients who may develop contrast-induced is nephropathy (CIN) and initiate prophylactictreatment to reduce the risk of morbidity-mortality, hospitalization and prolonged length of stay. In our study, we aimed to comparethe Zwolle, Cadillac and Syntax 2 (SS-2) risk scores that are currently used in the management of and predict mortality in patientswith ST elevation myocardial infarction (STEMI) in terms of predicting CIN development.Material and Methods: We enrolled 1622 patients who were diagnosed as STEMI and underwent primary coronary angiographybetween July 2014 and December 2018. 1381 patients were taken to the final analysis and two groups; CIN - (n=1295) and CIN +(n=86) were formed. Risk scores were compared in terms of CIN prediction.Results: The mean age of the patients was 62±8 years and 72% of them were males. SS-2, Zwolle and Cadillac scores were significantlyhigher in CIN+ group (all p values

PDF

___

1. Littnerova S, Kala P, Jarkovsky J, et al. GRACE Score among Six Risk Scoring Systems (CADILLAC, PAMI, TIMI, Dynamic TIMI, Zwolle) Demonstrated the Best Predictive Value for Prediction of Long-Term Mortality in Patients with ST-Elevation Myocardial Infarction. PLoS One 2015;10:e0123215.
2. Liu YH, Liu Y, Tan N, et al. Predictive value of GRACE risk scores for contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction before undergoing primary percutaneous coronary intervention. Int Urol Nephrol 2014;46:417-26.
3. Kul S, Uyarel H, Kucukdagli OT, et al. Zwolle risk score predicts contrast-induced acute kidney injury in STEMI patients undergoing PCI. Herz 2015;40:109-15.
4. Deek H, Newton P, Sheerin N, et al. Contrast media induced nephropathy: a literature review of the available evidence and recommendations for practice. Australian critical care: official journal of the Confederation of Australian Critical Care Nurses 2014;27:166-71.
5. Honicker T, Holt K. Contrast-Induced Acute Kidney Injury: Comparison of Preventative Therapies. Nephrol Nurs J 2016;43:109-16.
6. John M. Contrast-Induced Nephropathy (CIN): current state of the evidence on contrast media and prevention of CIN. AHRQ Comparative Effectiveness Reviews 2016;18.
7. Ando G, Trio O. Contrast-Induced Nephropathy After Primary Percutaneous Coronary Intervention: The Need for a Unifying Definition. Am J Cardiol 2017;119:169.
8. McDonald RJ, McDonald JS, Newhouse JH, et al. Controversies in Contrast Material-induced Acute Kidney Injury: Closing in on the Truth? Radiology 2015;277:627-32.
9. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol 2018;72:2231-64.
10. Sato A, Hoshi T, Kakefuda Y, et al. Effect of the Mehran risk score for the prediction of clinical outcomes after percutaneous coronary intervention. J Cardiol 2015;66:417- 22.
11. Abellas-Sequeiros RA, Raposeiras-Roubin S, Abu-Assi E, et al. Mehran contrast nephropathy risk score: Is it still useful 10 years later? J Cardiol 2016;67:262-7.
12. Serruys PW, Onuma Y, Garg S, et al. Assessment of the SYNTAX score in the Syntax study. EuroIntervention 2009;5:50-6.
13. Askin L, Akturk E. Association between SYNTAX II score and electrocardiographic evidence of no-reflow in patients with ST-segment elevation myocardial infarction. Turk Kardiyol Dern Ars 2018;46:455-63.
14. Nerlekar N, Ha FJ, Verma KP, et al. Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials. Circ Cardiovasc Interv 2016;9.
15. Cid Alvarez AB, Gomez-Pena F, Redondo-Dieguez A, et al. Prognostic impact of SYNTAX II score in patients with ST-elevation myocardial infarction undergoing Primary Percutaneous Coronary Intervention: analysis of a 4-year all-comers registry. EuroIntervention 2018;4.
16. Palmerini T, Genereux P, Caixeta A, et al. Prognostic value of the SYNTAX score in patients with acute coronary syndromes undergoing percutaneous coronary intervention: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) trial. J Am Coll Cardiol 2011;57:2389-97.
17. Head SJ, Farooq V, Serruys PW, et al. The SYNTAX score and its clinical implications. Heart 2014;100:169-77.
18. Mamoulakis C, Tsarouhas K, Fragkiadoulaki I, et al. Contrastinduced nephropathy: Basic concepts, pathophysiological implications and prevention strategies. Pharmacol Ther 2017;180:99-112.
19. Rencuzogullari I, Cagdas M, Karakoyun S, et al. Association of Syntax Score II with Contrast-induced Nephropathy and Hemodialysis Requirement in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Korean Circ J 2018;48:59-70.
20. Cinar T, Karabag Y, Ozan Tanik V, et al. The investigation of TIMI risk index for prediction of contrast-induced acute kidney injury in patients with ST elevation myocardial infarction. Acta Cardiol 2019;25:1-8.
21. Cinar T, Tanik VO, Arugaslan E, et al. The association of PRECISE-DAPT score with development of contrast-induced nephropathy in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiovasc Interv Ther 2019;34:207-15.