Comparison of glutathion-s-transferase A-4 expression values between lumbar spinal canal stenosis and lumbar discal hernia patients
Comparison of glutathion-s-transferase A-4 expression values between lumbar spinal canal stenosis and lumbar discal hernia patients
Aim: To compare the glutathione s-transferase α-4 (GSTA4) isoenzymes expression values in patients with lumbar spinal canalstenosis (LSCS) due to ligamentum flavum (LF) hypertrophy with patients no evidence of LF hypertrophy.Material and Methods: 27 LF specimens were obtained from patients with LSCS and 27 LF specimens were obtained from patientswith lumbar discal hernia (LDH). Firstly these LF samples were analyzed histologically to identify the fibrosis and elastin degradationvalues. Then GSTA4 isoenzyme values were measured and compared.Results: The mean LF thickness was significantly higher in the LSCS group than in the LDH group (6.72±0.86 and 3.1±0.7 mm,respectively, p
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- 1. Amudong A, Muheremu A, Abudourexiti T. Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta.J Int Med Res 2017; 45:2036-41.
- 2. Melancia JL, Francisco AF, Antunes JL. Spinal stenosis. In Handbook of clinical neurology 2014;119,541-9.
- 3. Awasthi YC, Ramana KV, Chaudhary P, et al. Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity. Free Radical Biology and Medicine 2017;111, 235-43.
- 4. Gokpinar D, Ozlece H K, Akyüz O, et al. Lomber Spinal Stenozda Ligamentum Flavum Hipertrofisinin Transforming Growth Factor Beta-1 Ile Ilişkisi. Journal of Contemporary Medicine 2017;7:13-6.
- 5. Habig WH, Pabst MJ, Fleischner G, et al. The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl AcadSci 1974;71:3879-82.
- 6. Karagianni P, Rallis D, Fidani L, et al. Glutathion-STransferase P1 polymorphisms association with broncopulmonary dysplasia in preterm infants. Hippokratia 2013;17:363-7
- 7. Yoshida M, Shima K, Taniguchi Y, et al.Hypertrophied ligamentum flavum in lumbar spinal canal stenosis. Pathogenesis and morphologic and immunohistochemical observation. Spine 1992;17:1353-60.
- 8. McMillan DH, van der Velden JL, Lahue KG, et al.Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π. JCI Insight 2016;2:85717.
- 9. Mazzetti AP, Fiorile MC, Primavera A, et al. Glutathione transferases and neurodegenerative diseases. Neurochem Int 2015;82:10-8.
- 10. Sairyo K, Biyani A, Goel VK, et al. Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation related scar tissue. Spine 2007;32:340- 7.
- 11. Ishimoto Y, Yoshimura N, Muraki S, et al. Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. Osteoarthritis and Cartilage 2013;21:783-8.
- 12. Yücetas SC, Çakır T. Decreased catalase expression is associated with ligamentum flavum hypertrophy due to lumbar spinal canal stenosis, Medicine 2019;98:15192.
- 13. Saito T, Yokota K, Kobayakawa K, et al. Experimental mouse model of lumbar ligamentum flavum hypertrophy. PloS one 2017;12:0169717.
- 14. Hansson T, Suzuki N, Hebelka H, et al. The narrowing of the lumbar spinal canal during loaded MRI: the effects of the disc and ligamentumflavum. European Spine J 2009;18:679-86.
- 15. Park JB, Kong CG, Suhl KH, et al. The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis. ClinOrthopSurg 2009;1:81-9.
- 16. Gopinathan P. Lumbar spinal canal stenosis-special features. journal of orthopaedics 2015;12:123.
- 17. Zhang K, Sun W, Liu XY, et al. Hypertrophy and fibrosis of the ligamentum flavum in lumbar spinal stenosis is associated with increased expression of LPA and LPAR1. Clinical spine surgery, 2017;30:189-91.
- 18. Sun C, Tian J, Liu X, et al. MiR-21 promotes fibrosis and hypertrophy of ligamentumflavum in lumbar spinal canal stenosis by activating IL-6 expression. Biochemical and biophysical research communications,2017;490:1106-11.
- 19. Nakamura T, Okada T. Endo M, Kadomatsu T, et al. Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis. PloS one, 2014;9:85542.
- 20. Yan B, Huang M, Zeng C, et al. Locally Produced IGF-1 Promotes Hypertrophy of the LigamentumFlavum via the mTORC1 Signaling Pathway. Cellular Physiology and Biochemistry, 2018;48:293-303.
- 21. Ronis M, Mercer K, Engi B, et al. Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. The American journal of pathology, 2017;187:418-30.
- 22. Ramsay EE, Dilda PJ. Glutathione S-conjugates as prodrugs to target drug-resistant tumors. Frontiers in pharmacology 2014;5:181.
- 23. Luo J, Chen G, Liang M, et al. Reduced Expression of Glutathione S-Transferase α4 Promotes Vascular Neointimal Hyperplasia in CKD. Journal of the American Society of Nephrology, 2018;29:505-17.
- 24. Xu Y, Gong B, Yang Y, et al. Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts. Transplantation 2010;89:409-16.