Clinical features associated with convulsive status epilepticus in patients with epilepsy

Aim: Status epilepticus (SE) is an important and distinct problem with its high morbidity and mortality. The need for early identificationof SE to predict the course and prognosis of epilepsy have led us to investigate the clinical features associated with SE in patientswith epilepsy in this study.Material and Methods: The information of the patients with epilepsy recorded comprised demographic features, type and etiology ofseizures, age of onset of epilepsy, frequency of seizures, mono- or polytherapy treatment, history of convulsive SE, triggering factorsfor SE and brain magnetic resonance imaging findings. The data also included patients’ family history of epilepsy and history offebrile seizures, mental retardation.Results: A total of 610 patients with epilepsy (291 men, 319 women) were included in the study. It was found that 49 (8%) of thepatients had at least one convulsive SE. Univariate logistic regression analysis showed that earlier onset of epilepsy, symptomatic/cryptogenic etiology, mental retardation, frequency of seizures ≥1/month, treatment with polytherapy, and abnormalities inneuroimaging are associated with SE (p=0.001, p

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1. Coeytaux A, Jallon P, Galobardes B, et al. Incidence of status epilepticus in French-speaking Switzerland: (EPISTAR). Neurology 2000;55:693-7.
2. Hesdorffer DC, Logroscino G, Cascino G, et al. Incidence of status epilepticus in Rochester, Minnesota, 1965- 1984. Neurology 1998;50:735-41.
3. Chin RF, Neville BG, Peckham C, et al. NLSTEPSS Collaborative Group. Incidence, cause, and shortterm outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet 2006;368:222-9.
4. Leitinger M, Trinka E, Giovannini G, et al. Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes. Epilepsia 2019;60:53-62.
5. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia 2015;56:1515-23.
6. Sánchez Fernández I, Goodkin HP, Scott RC. Pathophysiology of convulsive status epilepticus. Seizure 2019;68:16-21.
7. Burman RJ, Raimondo JV, Jefferys JGR, et al. The transition to status epilepticus: how the brain meets the demands of perpetual seizure activity. Seizure 2020;75:137-44.
8. Nelson SE, Varelas PN. Status Epilepticus, refractory status epilepticus, and super-refractory status epilepticus. Continuum (Minneap Minn) 2018;24:1683- 707.
9. Betjemann JP, Lowenstein DH. Status epilepticus in adults. Lancet Neurol 2015;14:615-24.
10. Neligan A, Shorvon SD. Frequency and prognosis of convulsive status epilepticus of different causes: a systematic review. Arch Neurol 2010;67:931-40.
11. Knake S, Rosenow F, Vescovi M, et al. Status Epilepticus Study Group Hessen (SESGH). Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia 2001;42:714-8.
12. Dham BS, Hunter K, Rincon F. The epidemiology of status epilepticus in the United States. Neurocrit Care 2014;20:476-83.
13. Lv RJ, Wang Q, Cui T, et al. Status epilepticus-related etiology, incidence and mortality: A meta-analysis. Epilepsy Res 2017;136:12-7.
14. Trinka E, Höfler J, Zerbs A. Causes of status epilepticus. Epilepsia 2012;53:127-38.
15. Fountain NB. Status epilepticus: risk factors and complications. Epilepsia 2000;41 Suppl 2:S23-30.
16. Logroscino G, Hesdorffer DC, Cascino G, et al. Mortality after a first episode of status epilepticus in the United States and Europe. Epilepsia 2005;46 Suppl 11:46-8.
17. Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58:512-21.
18. Britton JW. Antiepileptic drug withdrawal: literature review. Mayo Clin Proc 2002;77:1378-88.
19. Yildiz EP, Gunes D, Bektas G, et al. Predictive factors of drug-resistant epilepsy in children presenting under 2 years of age: experience of a tertiary center in Turkey. Acta Neurol Belg 2018;118:71-5.
20. Shankar R, Rowe C, Van Hoorn A, et al. Under representation of people with epilepsy and intellectual disability in research. PLoS One 2018;13:e0198261.
21. Doran Z, Shankar R, Keezer MR, et al. Managing anti-epileptic drug treatment in adult patients with intellectual disability: a serious conundrum. Eur J Neurol 2016;23:1152-7.
22. Devinsky O, Asato M, Camfield P, et al. Delivery of epilepsy care to adults with intellectual and developmental disabilities. Neurology 2015;85:1512- 21.
23. Shinnar S, Pellock JM, Moshé SL, et al. In whom does status epilepticus occur: age-related differences in children. Epilepsia 1997;38:907-14.
24. Dalby NO, Mody I. The process of epileptogenesis: a pathophysiological approach. Curr Opin Neurol 2001;14:187-92.
25. Sperk G, Drexel M, Pirker S. Neuronal plasticity in animal models and the epileptic human hippocampus. Epilepsia 2009;50 Suppl 12:29-31.
26. Wirrell E, Wong-Kisiel L, Mandrekar J, et al. Predictors and course of medically intractable epilepsy in young children presenting before 36 months of age: a retrospective, population-based study. Epilepsia 2012;53:1563-9.
27. Seker Yilmaz B, Okuyaz C, Komur M. Predictors of intractable childhood epilepsy. Pediatr Neurol 2013;48:52-5.
28. Callaghan BC, Anand K, Hesdorffer D, et al. Likelihood of seizure remission in an adult population with refractory epilepsy. Ann Neurol 2007;62:382-9.
29. Voll A, Hernández-Ronquillo L, Buckley S, et al. Predicting drug resistance in adult patients with generalized epilepsy: A case-control study. Epilepsy Behav 2015;53:126-30.
30. Geerts A, Brouwer O, Stroink H, et al. Onset of intractability and its course over time: The Dutch study of epilepsy in childhood. Epilepsia 2012;53:741-51.
31. Berg AT, Shinnar S, Levy SR, et al. Early development of intractable epilepsy in children: a prospective study. Neurology 2001;56:1445-52. Erratum in: Neurology 2001;57:939.
32. Hitiris N, Mohanraj R, Norrie J, et al. Predictors of pharmacoresistant epilepsy. Epilepsy Res 2007;75:192-6.
33. Kalilani L, Sun X, Pelgrims B, et al. The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis. Epilepsia 2018;59:2179-93.
34. Xue-Ping W, Hai-Jiao W, Li-Na Z, et al. Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis. Medicine (Baltimore) 2019;98:e16402.