Cancer is seen more in older female patients with psoriasis : A cross-sectional study in 1551 patients
Cancer is seen more in older female patients with psoriasis : A cross-sectional study in 1551 patients
Aim: The aim of this study was to establish the potential risk of the development of malignancy in the patients with psoriasis.Material and Methods: A retrospective analysis of psoriasis cases between January 2017 to August 2018 attending the dermatologyclinic at Karabuk Research and Training Hospital was carried out. Patients with psoriasis were screened whether they have anymalignant disease and associated chronic disease including diabetes mellitus and hypertension by using hospital data system.Suspected cases regarding psoriasis or malignant disease were excluded. Findings were compared according to demographiccharacteristics of the patients.Results: A total of 1551 patients with psoriasis was evaluated in the study time. 30 patients (22 women, 8 men) were found to havemalignancy. The most commonly seen malignancy was stomach cancer in women and prostate cancer in men. 2% of patients withpsoriasis had cancer. This rate was 2.5% in female patients and 1% in male patients (p
___
- 1. Ogawa E, Sato Y, Minagawa A, et al. Pathogenesis of psoriasis
and development of treatment.J Dermatol 2018;45:264-72.
- 2. Yunusova NV, Kondakova IV, Kolomiets LA, et al. The role
of metabolic syndrome variant in the malignant tumors
progression. Diabetes Metab Syndr 2018;12:807-12.
- 3. Gisondi P, Fostini AC, Fossà I, et al. Psoriasis and the
metabolic syndrome.Clin Dermatol 2018;36:21-8.
- 4. Kimball AB, Sundaram M, Cloutier M, et al. ıncreased
prevalence of cancer in adult patients with psoriasis in the
united states: a claims basedanalysis. J Drugs Dermatol
2018;17:180-6.
- 5. Rademaker M, Rubel DM, Agnew K, et al. Psoriasis and
cancer. An australian/new zealand narrative. Australas J
Dermatol 2019;60:12-8.
- 6. Reddy SP, Martires K, Wu JJ. The risk of melanoma and
hematologic cancers in patients with psoriasis. J Am Acad
Dermatol. 2017;76:639-47.
- 7. Chiesa Fuxench ZC, Shin DB, Ogdie Beatty A, et al. The risk of
cancer in patients with psoriasis: a population-based cohrt
study in the health ımprovement network. JAMA Dermatol
2016;152:282-90.
- 8. Mendonça FM, de Sousa FR, Barbosa AL, et al. Metabolic
syndrome and risk of cancer: which link? Metabolism.
2015;64:182-9.
- 9. Eheim A, Medrikova D, Herzig S. Immune cells and metabolic
dysfunction.Semin Immunopathol 2014;36:13-25.
- 10. Emre S, Metin A, Demirseren DD, et al. The relationship
between oxidative stress, smoking and the clinical severity
of psoriasis. J.Eur.Acad.Dermatol.Venereol 2013;27:e370-
75.
- 11. Reuter S, Gupta SC, Chaturvedi MM, et al. Oxidative stress,
inflammation, and cancer: how are they linked? Free Radic
Biol Med 2010;49:1603-16.
- 12. Stern RS; PUVA Follow-Up Study. The risk of squamous
cell and basal cell cancer associated with psoralen and
ultraviolet A therapy: a 30-year prospective study.J Am Acad
Dermatol 2012;66:553-62.
- 13. Pouplard C, Brenaut E, Horreau C, et al. Risk of cancer
in psoriasis: a systematic review and meta-analysis of
epidemiological studies. J Eur Acad Dermatol Venereol
2013;27:36-46.
- 14. Arellano FM, Wentworth CE, Arana A, et al. Risk of lymphoma
following exposure to calcineurin inhibitors and topical
steroids in patients with atopic dermatitis. J Invest Dermatol
2007;127:808-16.
- 15. Kobayashi D, Kuriyama N, Hirano K, et al. Malignancy
incidences by glycemic control among diabetic patients.
Endocr Connect 2018. Dec 1. Pii ec 0355
- 16. Radišauskas R, Kuzmickienė I, Milinavičienė E, et al.
Hypertension, serum lipids and cancer risk: a review of
epidemiological evidence. Medicina (Kaunas) 2016;52:89-
98.
- 17. Cohen AD, Weitzman D, Dreiher J. Psoriasis and hypertension:
a case-control study. Acta Derm venereol 2010;90:23-6.
- 18. White MC, Holman DM, Boehm JE, et al. Age and cancer
risk: a potentially modifiable relationship. Am J Prev Med
2014;46:S7-15.
- 19. International Diabetes Federation. IDF Diabetes Atlas,
6th edition. Brussels, Belgium: International Diabetes
Federation, 2013.
- 20. Arici M, Turgan C, Altun B, et al. Hypertension incidence
in Turkey (HinT): a population-based study. J Hypertens
2010;28:240-4.
- 21. Frentz G, Olsen JH. Malignant tumours and psoriasis: a
follow-up study. Br J Dermatol 1999;140:237-42.
- 22. Egeberg A, Thyssen JP, Gislason GH, et al. Skin cancer in
patients with psoriasis. J Eur Acad Dermatol Venereol
2016;30:1349-53.
- 23. Paradisi A, Didona B, Tabolli S, et al. Reduced frequency of
non-melanoma skin cancer in 72,739 patients with psoriasis:
a retrospective study. Eur J Dermatol 2017;27:359-62.
- 24. Prizment AE, Alonso A, Folsom AR, et al. Association
between psoriasis and incident cancer: the Iowa’s Women’s
Health Study.Cancer Causes Control 2011;22:1003-10.
- 25. Lee JH, Kim HJ, Han KD, Et al. Cancer risk in 892 089
patients with psoriasis in Korea: a nationwide populationbased
cohort study. J Dermatol 2019;46:95-102.
- 26. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer
incidence and mortality patterns in Europe: estimates for 40
countries in 2012. Eur J Cancer. 2013;49:1374-403.
- 27. Dai H, Li WQ, Qureshi AA, et al. Personal history of psoriasis
and risk of nonmelanoma skin cancer (NMSC) among
women in the United States: a population-based cohort
study. J Am Acad Dermatol 2016;75:731-5.