Gökhan ÇİCEK, Eser AÇIKGÖZ, Sadık Kadri AÇIKGÖZ

Platelet to lymphocyte ratio is associated with contrast induced nephropathy after primary percutaneous coronary intervention for ST-elevation myocardial infarction section

Aim: Platelet to lyphocyte ratio is a novel inflammatory marker which is correlated with markers such as C-reactive protein andassociated with cardiovascular outcomes in coronary artery disease. Contrast iduced nephropathy is an important complication ofpecutaneous coronary intervention. Association between platelet to lymphocyte ratio and contrast induced nephropathy developmentafter primary percutaneous coronary intervention with a diagnosis of ST-elevation myocardial infarction was evaluated in this study.Material and Methods: Data of 3352 consecutive patients who underwent primary percutaneous coronary intervention for STelevationmyocardial infarction were analysed. Independent predictors of contrast induced nephropathy were investigated withlogistic regression analysis.Results: Patients with contrast induced nephropathy had significantly higher platelet to lymphocyte ratio (150.0 vs 119.1, p=0.001).In multivariate logistic regression analysis platelet to lymphocyte ratio (OR 1.100, 95% CI 1.050-1.130, p=0.033) was found as anindependent predictor of contrast induced nephropathy.Conclusion: Platelet to lymphocyte ratio may have a role to predict contrast induced nephropathy in patients undergoing primarypercutaneous coronary intervention for ST-elevation myocardial infarction.

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1. Mehran R, Aymong ED, Nikolsky E, et al. A simple risk score form prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol 2004;44:1393-9.
2. Senoo T, Motohiro M, Kamihata H, et al. Contrastinduced nephropathy in patients undergoing emergency percutaneous coronary intervention for acute coronary syndrome. Am J Cardiol 2010;105:624-8.
3. Goldfarb S, McCullough PA, McDermott J, et al. Contrastinduced acute kidney injury: specialty-specific protocols for interventional radiology, diagnostic computed tomography radiology, and interventional cardiology. Mayo Clin Proc 2009;84:170-9.
4. Finn WF. The clinical and renal consequences of contrastinduced nephropathy. Nephrol Dial Transplant 2006;21:i2- 10.
5. Cuddy E, Robertson S, Cross S, et al. Risks of coronary angiography. Lancet 2005;366:1825.
6. Gary T, Pichler M, Belaj K, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One 2013;8:676-88.
7. Azab B, Shah N, Akerman M, et al. Value of platelet/ lymphocyte ratio as a predictor of all-cause mortality after non- ST elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326-34.
8. Kurtul A, Yarlioglues M, Murat SN, et al. Usefulness of the platelet-to lymphocyte ratio in predicting angiographic reflow after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Am J Cardiol 2014;114:342-7.
9. Demircelik MB, Kurtul A, Ocek H, et al. Association between platelet-to-lymphocyte ratio and contrast-induced nephropathy in patients undergoing percutaneous coronary intervention for acute coronary syndrome. Cardiorenal Med 2015;5:96-104.
10. Kocas C, Yildiz A, Abaci O, et al. Platelet-to-Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. Angiology 2015;66:964-8.
11. Lazaros G, Tsiachris D, Tousoulis D, et al. In-hospital worsening renal function is an independent predictor of oneyear mortality in patients with acute myocardial infarction. Int J Cardiol 2012;155:97-101.
12. McCullough PA. Contrast-induced acute kidney injury. J Am Coll Cardiol 2008;51:1419-28.
13. Recio-Mayoral A, Chaparro M, Prado B, et al. The renoprotective effect of hydration with sodium bicarbonate plus N-acetylcysteine in patients undergoing emergency percutaneous coronary intervention: the RENO study. J Am Coll Cardiol 2007;49:1283-8.
14. McCullough PA, Stacul F, Becker CR, et al; Contrast-induced nephropathy (cin) consensus working panel: executive summary. Rev Cardiovasc Med 2006;7:177-97.
15. Fox CS, Muntner P, Chen AY, et al. Short-term outcomes of acute myocardial infarction in patients with acute kidney injury: a report from the national cardiovascular data registry. Circulation 2012;125: 497-504.
16. Katsiki N, Athyros VG, Karagiannis A, et al. Contrast-induced nephropathy: an ‘‘all or none’’ phenomenon? Angiology 2015;66:508-13.
17. Kadri Z, Danchin N, Vaur L, et al. USIC Major impact of admission glycaemia on 30 day and one year mortality in non-diabetic patients admitted for myocardial infarction: results from the nationwide French USIC 2000 study. Heart 2006;92:910-5.
18. Goldenberg I, Matetzky S. Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategies. CMAJ 2005;172:1461-71.
19. Ronco C, Haapio M, House AA, et al. Cardiorenal syndrome. J Am Coll Cardiol 2008;52:1527-39.
20. Heyman SN, Reichman J, Brezis M. Pathophysiology of radiocontrast nephropathy: a role for medullary hypoxia. Invest Radiol 1999;34:685-91.
21. Kurtul A, Murat SN, Yarlioglues M, et al. Association of platelet-to-lymphocyte ratio with severity and complexity of coronary artery disease in patients with acute coronary syndromes. Am J Cardiol 2014;114:972-8.
22. Çiçek G, Açıkgoz SK, Bozbay M, et al. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio combination can predict prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Angiology 2015;66:441-7.
23. Gasparyan AY, Ayvazyan L, Mukanova U, et al. The plateletto- lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med 2019;39:345-57.