Can platelet Iymphocyte ratio and neutrophil to lymphocyte ratio be used as prognostic predictors for hepatocellular carcinoma?
Can platelet Iymphocyte ratio and neutrophil to lymphocyte ratio be used as prognostic predictors for hepatocellular carcinoma?
Aim: To investigate the predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratios for hepatocellular carcinomaoutcomesMaterial and Methods: 37 hepatocellular carcinoma patients were retrospectively collected. All of the hepatocellular carcinomapatients were treated with conventional methods; transarterial chemoembolization, radiofrequency ablation or both. The patientand tumor characteristics, platelet to lymphocyte ratio and neutrophil to lymphocyte ratio were recorded. The association betweenplatelet to lymphocyte ratio and neutrophil to lymphocyte ratio and tumor free survival rates, recurence rates, need of repeatedconventional therapy were analyzed.Results: The mean MELD (model for end stage liver disease) score of 37 hepatocellular carcinoma patients was 10.75±4.484(mean age 59.59±17.23 years). High platelet to lymphocyte ratio and neutrophil to lymphocyte ratio were found to be associatedwith hepatocellular carcinoma recurrence (p0.05). Platelet to lymphocyte ratio and neutrophil to lymphocyte ratios were significantlyhigh in patients who had repated transarterial chemoembolisation, radiofrequency ablation or both (p
___
- 1. Bosch FX, Ribes J, Cleries R, et al. Epidemiology of
hepatocellular carcinoma. Clin Liver Dis 2005;9:191-211.
- 2. Thomas MB, Jaffe D, Choti MM, et al. Hepatocellular
carcinoma; consensus recommendations of the National
Cancer Institute Clinical Trials Planning Meeting. J Clin
Oncol 2010;28:3994-4005.
- 3. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation,
and cancer. Cell 2010;140:883-99.
- 4. European association for the study of the liver; european
organisation for research and treatment of cancer.
EASLEORTC clinical practice guidelines: management of
hepatocellular carcinoma. J Hepatol 2012;56:908-43.
- 5. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation
for the treatment of small hepatocellular carcinomas in
patients with cirrhosis. N Engl J Med 1996;334:693-9.
- 6. Prasad KR, Young RS, Burra P, et al. Summary of candidate
selection and expanded criteria for liver transplantation
for hepatocellular carcinoma: a review and consensus
statement. Liver Transpl 2011;17:S81-9.
- 7. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for
hepatocellular carcinoma: expansion of the tumor size
limits does not adversely impact survival. Hepatology
2001;33:1394-403.
- 8. Zheng SS, Xu X, Wu J, et al. Liver transplantation for
hepatocellular carcinoma: Hangzhou experiences.
Transplantation 2008;85:1726-32.
- 9. Li WX, Li Z, Gao PJ, et al. Histological differentiation
predicts post-liver transplantation survival time. Clin Res
Hepatol Gastroenterol 2014;38:201-8.
- 10. Chen Y, Chen K, Xiao X, et al. Pretreatment neutrophil-tolymphocyte
ratio is correlated with response to neoadjuvant
chemotherapy as an independent prognostic indicator in
breast cancer patients: a retrospective study. BMC Cancer
2016;16:320-5.
- 11. Wu SJ, Lin YX, Ye H, et al. Lymphocyte to monocyte ratio
and prognostic nutritional index predict survival outcomes
of hepatitis B virusassociated hepatocellular carcinoma
patients after curativehepatectomy. J Surg Oncol
2016;114:202-10.
- 12. Toso C, Asthana S, Bigam DL. Reassessing selection criteria
prior to liver transplantation for hepatocellular carcinoma
utilizing the Scientific Registry of Transplant Recipients
database. Hepatology 2009;49:832-8.
- 13. You J, Zhu GQ, Xie L, et al. Preoperative platelet to lymphocyte
ratio is a valuable prognostic biomarker in patients with
colorectal cancer. Oncotarget 2016;7:25516-27.
- 14. Lai Q, Castro Santa E, Rico Juri JM, et al. Neutrophil and
platelet-to-lymphocyte ratio as new predictors of dropout
and recurrence after liver transplantation for hepatocellular
cancer. Transpl Int 2014;27:32-41.