Kronik Akciğer Hastalıklarında İlaç Geliştirme ve Güncel Tedavi Stratejileri

Kronik akciğer hastalıkları, ülkemizde ve tüm dünyada yaygın olarak görülen ve mevcut tedavi yöntemleri ile istenilen terapötik etkinin sağlanamadığı hastalık grubudur. Mali yükü ne kadar yüksek olsa da yeni tedavi yaklaşımlarına ihtiyaç duyulmaktadır. Fakat birçok ilaç adayı molekül, zayıf etkinliği ve yan tesir profilinin çeşitliliği nedeniyle ilaç geliştirme basamaklarını tamamlayıp klinikte güncel tedavide kullanılamamaktadır. İlaç adayının farmakokinetik özelliklerinin uygun olmaması, biyoyararlanımının düşük olması yada preklinik aşamada in vivo deney modellerinin akciğer hastalıklarını bir bütün halinde taklit edememesinden dolayı araştırmalar uzun sürmekte ve oldukça maliyetli olmaktadır. 10000 aday molekülden yalnızca bir tanesi faz aşamalarını tamamlayıp bir endikasyon dahilinde akciğer hastalıklarının güncel tedavisinde kullanılmak üzere piyasaya sürülmektedir. Bu oranı yükseltmek için akciğer hastalıklarının patofizyolojisi ile birlikte ilaç adayının etki mekanizması göz önünde bulundurularak yeni tedavi stratejileri geliştirmek gerekmektedir

Anahtar Kelimeler:

Akciğer Hastalıkları, Kronik Hastalık, İlaç Keşfi

Drug Development and Current Treatment Strategies in Chronic Lung Diseases

Chronic lung diseases are a group of diseases that are widespread in our country and all over the world and in which the desired therapeutic effect can not be achieved with existing treatment modalities. No matter how high the financial burden is, new treatment approaches are needed. However, many drug candidates are unable to complete the drug development steps and clinically use it in current therapy due to the diversity of the molecule, poor efficacy and side effect profile. Because inadequate pharmacokinetic properties of the drug candidate, low bioavailability, and in vivo experimental models in the preclinical phase can not mimic lung diseases as a whole, the research is long and costly. Only one out of 10000 nominal molecules have been used to complete the phase trials and to be used in the current treatment of pulmonary diseases within an indication. In order to increase this rate, it is necessary to develop new treatment strategies by considering the pathophysiology of lung diseases and the mechanism of action of drug candidates

Keywords:

Lung Diseases, Chronic Disease, Drug Discovery,

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