Neisseria gonorrhoeae’de kinolon direnci: İstanbul Tıp Fakültesi 2002-2006

Üretritli erkek hastalardan 2002-2006 yıllarında izole edilen kinolon dirençli Neisseria gonorrhoeae (KDNg) suşları bildirilmiştir. Bu süre için ortalama KDNg oranı % 33 (18/54 izolat), penisilin ve tetrasikline dirençli suş oranları sırasıyla % 62 ve % 61 olarak saptanmıştır. Seftriakson, sefoksitin ve sefuroksime dirençli suş saptanmamıştır. Yüksek direnç oranları nedeniyle, kinolonlar, penisilin ve tetrasiklin gonokok infeksiyonlarının ampirik tedavisinde kullanılmamalıdır.

Anahtar Kelimeler:

İlaç direnci, mikrobiyal, Kinolonlar, Neisseria gonorrhoeae, Mikrobiyal duyarlılık testleri

Quinolone resistance in neisseria gonorrhoeae: Istanbul Medical Faculty 2002-200

Quinolone-resistant Neisseria gonorrhoeae (QRNg) strains isolated from male patients with urethritis in 2002-2006 were reported. In this period the mean percentage of QRNg was detected as 33 % (18/54 isolates) and, penicillin- and tetracycline-resistant strains were 62 % and 61 %, respectively. No resistant strain was detected for ceftriaxone, cefoxitin and cefuroxime. Due to their high resistance rates, quinolones, penicillin and tetracycline should not be used in empirical treatment of gonococcal infections.

Keywords:

Drug Resistance, Microbial, Quinolines, Neisseria gonorrhoeae, Microbial Sensitivity Tests,

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