Mete EYİGÖR, Berna GÜLTEKİN, NERİMAN AYDIN

Klinik örneklerden izole edilen Streptococcus pneumoniae kökenlerinin antibiyotik direnci

Ekim 2004-Aralık 2006 tarihleri arasında çeşitli klinik örneklerden izole edilen 83 Streptococcus pneumoniae kökeninin antibiyotik direnci Kirby-Bauer disk difüzyon yöntemi ile araştırılmış, disk difüzyon yöntemi ile oksasiline direnç saptanan kökenlerin E-test yöntemi ile penisilin için minimal inhibitör konsantrasyon değerleri saptanmıştır. Kökenlerin % 64’ü penisiline duyarlı, % 35’i düşük düzeyde dirençli, % 1’i yüksek düzeyde dirençli bulunmuştur. Test edilen kökenlerde vankomisine direnç saptanmazken, orta derecede duyarlılar dahil eritromisine % 35, tetrasikline % 20, levofloksasine % 4 oranında direnç saptanmıştır. Pnömokok suşlarında penisiline düşük düzeyde dirençli olanların oranı yüksek bulunmuştur. Levofloksasinin, düşük direnç oranı nedeniyle, penisiline dirençli kökenlerle olan infeksiyonların tedavisinde iyi bir seçenek olabileceği düşünülmüştür.

Anahtar Kelimeler:

İlaç direnci, bakteriyel, Anti-enfektif ajanlar, Mikrobiyal duyarlılık testleri, Penisilinler, Streptococcus pneumoniae, Disk difüzyon antimikrobiyal testleri

Antibiotic resistance of Streptococcus pneumoniae strains ısolated from clinical specimens

The resistance to antibiotics in 83 Streptococcus pneumoniae strains isolated between October 2004 - December 2006 was investigated by Kirby-Bauer disk diffusion method. The minimal inhibitor concentration values of penicillin in oxacillin-resistant strains detected by disk diffusion method were determined by E-test. Sixtyfour percent of 83 strains were susceptible, 35 % were low-level resistant and 1 % were high-level resistant to penicilin. While there was no resistance to vancomycin, the resistance rates of the isolates to erythromycin, tetracycline and levofloxacin were 35 %, 20 % and 4 % (included intermediate strains), respectively. Due to the low resistance, levofloxacin may be considered as a good choice for infections by penicillin-resistant strains.

Keywords:

Drug Resistance, Bacterial, Anti-Infective Agents, Microbial Sensitivity Tests, Penicillins, Streptococcus pneumoniae, Disk Diffusion Antimicrobial Tests,

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