Cemal ÜSTÜN, Mehmet Faruk GEYİK, ALPER AVCI, ZAFER PARLAK, Celal AYAZ

İmipenem ilişkili konvülziyon: Olgu sunumu

Beta-laktam grubu antibiyotiklerinin nadir görülen yan etkilerinden biri de konvülziyondur. Acil servise yüksek ateş, öksürük ve solunum sıkıntısıyla gelen dokuz yaşında erkek hasta ampiyem tanısıyla yatırılmış, ampiyem materyalinden yapılan kültürde GSBL positif Pseudomonas aeruginosa üremiştir. Tedavide imipenem/silastatin ile birlikte amikasin verilmiştir. Klinik ve laboratuvar olarak düzelen hastada tedavinin 18. gününde tonik-klonik kasılmalarla seyreden konvülziyon gelişmiş, konvülziyonlar imipenem/silastatin tedavisine bağlanmış ve antibiyoterapi kesilmiştir. Antiepileptik tedavi başlanan hastada yapılan incelemelerde konvülziyonu açıklayacak başka bir patoloji bulunamamıştır. Hasta yatışının 21. gününde şifa ile tabucu edilmiştir.

Anahtar Kelimeler:

Ampiyem, İlaç aşırı duyarlılığı, Epilepsi, tonik-klonik, Erkek, Çocuk, İmipenem, Tedavi sonucu, İlaç tedavisi

Imipenem associated convulsion: Case report

Convulsion is an infrequent side effect of beta-lactam antibiotics. A nine-years-old boy patient admitted to the emergency room with fever, coughing, and dyspnea. Patient was hospitalized with diagnosis of empyema and ESBL positive Pseudomonas aeruginosa was isolated on blood agar culture of empyema material. The patient was treated with imipenem/cilastatin and amikacin and improved clinically, but developed convulsion with tonic-clonic myospasms at 18th day of therapy. The treatment of imipenem withdrawn because of its close relation with convulsions, and antiepileptic therapy was started. We could not find any other possible etiologic cause of convulsion by physical examination and laboratory evaluation. The patient was discharged with full recovery at 21th day of hospitalization.

Keywords:

Empyema, Drug Hypersensitivity, Epilepsy, Tonic-Clonic, Male, Child, Imipenem, Treatment Outcome, Drug Therapy,

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