Özlem ŞAHAN, Artun YIBAR, Gökçen DİNÇ, Zafer ATA, Hamit Kaan MÜŞTAK

Extended spectrum beta-lactamase activity and multidrug resistance of Salmonella serovars isolated from chicken carcasses from different regions of Turkey

Bu çalışma, tavuk karkaslarından izole edilen Salmonella serovarlarının çoklu ilaç dirençliliği ve geniş spektrumlu betalaktamaz aktivitesinin araştırılması amacıyla yürütülmüştür. Çalışmada, 930 tavuk karkasından izole edilen 99 Salmonella izolatı 12farklı antimikrobiyale karşı test edilmiştir. Salmonella izolatlarının antimikrobiyallere karşı direnç oranları sırasıyla; ampisiline%35.3 (35/99), tetrasikline %33.3 (33/99), amoksisilin -clavulanic asite %29.2 (29/99), nalidiksik asite %18.1 (18/99), kloramfenikole %17.1 (17/99), aztreonama %16.1 (16/99), trimetoprim -sulfametoksazole %12.1 (12/99), gentamisine %4 (4/99), seftazidime %1.0(1/99) olarak belirlenmiştir. İzolatların %46.4 (46/99)ünün çoklu ilaç dirençli olarak iki veya daha fazla antibiyotiğe dire nçgösterdiği tespit edilmiştir. Geniş spektrumlu beta laktamaz aktivitesi %1.0 (1/99) oranında bulunmuştur. Ayrıca, S. Typhimurium%26.2 (28/99), S. Infantis %16.1 (16/99), S. Hadar %12.1 (10/99) ve S. Branderburg %9.0 (9/99) çalışmadaki predominatserovarlardır. Sonuç olarak, antimikrobiyal direnç ve çoklu ilaç direnç oranları, dire nç profillerinin monitorize edilmesininSalmonella enfeksiyonlarının tedavi stratejilerinin planlanması için önemli olduğunu göstermiştir.

Türkiye nin çeşitli bölgelerindeki tavuk karkaslarından izole edilen Salmonella seovarlarının çoklu ilaç dirençliliği ve geniş spektrumlu beta laktamaz aktivitesi

This research was conducted to investigate the extended spectrum beta -lactamase activity and multidrugresistance of Salmonella serovars isolated from chicken carcasses. For this purpose, 99 Salmonella isolates from 930 chickencarcasses were tested against 12 different antimicrobials. The resistance rates of Salmonella isolates to antimicrobials were asfollows: 35.3% (35/99) to ampicillin, 33.3% (33/99) to tetracycline, 29.2% to amoxicillin -clavulanic acid, 18.1% (18/99) to nalidixicacid, 17.1% (17/99) to chloramphenicol, 16.1% (16/99) to aztreonam, 12.1% (12/99) to tr imethoprim -sulfamethoxazole, 4% (4/99) togentamicin, 1.0% (1/99) to ceftazidime. Of the isolates 46.4% (46/99) were found to be resistant to two or more antimicrobials as amultidrug resistance. Extended spectrum beta -lactamase activity was detected in 1.0% (1/99) of the isolates. Furthermore, S.Typhimurium 26.2% (28/99), S. Infantis 16.1% (16/99), S. Hadar 12.1% (10/99) and S. Branderburg 9.0% (9/99) were found to bethe predominant serovars . In conclusion, antimicrobial resistance and also multidrug res istance rates of Salmonella isolates in thisstudy, indicated that monitoring of antimicrobial resistance profiles is important for Salmonella infections to plan treatmentstrategies.

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