Aysun TEKELİ, Nurettin BORAN, Zeliha CÜYLAN, Taner TURAN, Hakan GÖKÇİN, Deniz ÇAVUȘOĞLU, Gökhan TULUNAY, Mehmet Faruk KÖSE

Primer Odağı Safra Kesesi Olan Metastatik Over Tümörleri: Üç Olgunun Sunumu

Amaç: Primer odağı safra kesesi ve safra yolları olan metastatik over kanseri oldukça nadirdir. Bu çalıșmada overe metastaz yapmıș olan üç safra kesesi kanseri sunuldu. Olgu: Olguların tanı yașı 67, 70 ve 71’di. İkisinde tanı, preoperatif dönemde bilgisayarlı tomografi ve gastrointestinal sistem endoskopisiyle değerlendirilmiș olmasına rağmen intraoperatif olarak frozen/section ile konulabildi. İki olguda bilateral ovarian patoloji söz konusuydu. CA 125 düzeyi iki hastada normal değerlerin üzerindeydi. Bir hastada yaygın intraabdominal tutulum mevcuttu ve bu hastada safra kesesindeki patoloji preoperatif dönemde saptandı. Asitin (Ascites’in) olduğu bu olguda CA 125 düzeyi 489,82 IU/ml’ydi. Sonuç: Metastatik over tümörlerinin preoperatif ve intraoperatif dönemdeki klinik ve laboratuar bulguları ayırıcı tanıda yeterli olmayabilir. Frozen/section bu ayırımda belirleyicidir.

Anahtar Kelimeler:

Over kanseri, Safra kesesi kanseri, Metastaz

Primer odağı safra kesesi olan metastatik over tümörleri: üç olgunun sunumu

Keywords:

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Moore RG, Chung M, Granai GO, Ga- jewski W, Steinhoff MM. Incidence of metastasis to the ovaries from nongenital tract tumors. Gynecol Oncol 2004; 93: 87-91.
Hashimato YD, Yamamoto T, Shoji K, et al. Metastatic ovarian tumors: a review of 68 cases. Gynecol Oncol 2003; 89: 314- 317.
Ulbright TM, Roth LM, Stehman FB. Secondary ovarian neoplasia: a clinicopa- thologic study of 35 cases. Cancer 1984; 53: 1164-1174.
Turan T, Aykan B, Koç S, et al. Analysis of metastatic ovarian tumors from extra- genital primary site. Tumori 2006; 92: 493-497
Young RH, Path FRC, Scully RE. Metas- tatic tumors of the ovary In: Kurman RJ (Ed), Blaustein’s Pathology of the Female Genital Tract, 5. Edition, 2002; 1063- 1101.
Ayhan A, Güvenal T, Salman MC, et al. The role of cytoreductive surgery in non- genital cancers metastatic to the ovaries. Gynecol Oncol 2006; 98: 235-241
Mazur MT, Hsueh S, Gersell DJ. Metas- tases to the female genital tract: analysis of 325 cases. Cancer 1984; 53: 1978-1984.
Stewart CJR, Brennan BA, Hammond IG, et al. Accuracy of frozen section in distinguishing primary ovarian neoplasia from tumors metastatic to the ovary. Int. J Gynecol Pathol 2005; 24: 356-362
Jarvi K, Kelty CJ. Bilateral ovarian metas- tases from carcinoma of the gallbladder. Gynecol Oncol 2006; 103: 361-362
Lee KR. Young RH. The distinction between primary and metastatic mucin- ous carcinomas of the ovary: Gross and histologic findings in 50 cases. Am J Surg Pathol 2003; 27: 281-292
Hibner M, Greenspan D. Ovarian metas- tases from the biliary tract, pancreas and liver carcinomas. CME Journal of Gyne- col Oncol 2004; 9: 125-128
Jarvi K, Kelty CJ. Bilateral ovarian metas- tases from carcinoma of the gallbladder. Gynecol Oncol 2006; 103: 361-362
García A, De la Torre J, Castellví J, et al. Ovarian metastases caused by cholangi- ocarcinoma: a rare Krukenberg’s tumour simulating a primary neoplasm of the ovary: a two-case study. Arch Gynecol Obstet 2004; 270: 281-284
Chu PG, Schwarz RE, Lau SK, et al. Immunohistochemical staining in the di- agnosis of pancreatobilier and ampulla of vater adenocarcinoma: application of CDX2, CK17, MUCI and MUC2. Am J Surg Pathol 2005; 29: 359-367
Goldstein NS, Basis D, Uzieblo A. WT1 is an integral component of antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasm. Am J Clin Pathol 2001; 116:246-252
14Chang TC, Changchien CC, Tseng CW, et al. Retrograde lymphatic spread: a likely route for metastatic ovarian cancers of gastrointestinal origin. Gynecol Oncol 1997; 66: 372-377
McGill F, Ritter DB, Rickard C, et al. Management of Krukenberg tumors: An 11-years experience and review of the li- terature. Prim Care Update Ob Gyn 1998; 5 : 157-158
Young RH, Path FRC, Scully RE. Metas- tatic tumors of the ovary. In: Kurman RJ (ed), Blaustein’s Pathology of the Female Genital Tract, 5. Edition, 2002; 1063- 1101.