Zeliha GÜZELKÜÇÜK, Derya ÖZYÖRÜK, Arzu YAZAL ERDEM, İnci YAMAN BAJİN, Ayça KOCA YOZGAT, Can Barış AKER, Can İhsan ÖZTORUN, Suna EMİR, Ahmet DEMİR, Ayşe ERTOY, Emrah ŞENEL

Pediatrik Hastalarda Malign Karaciğer Tümörlerinin Değerlendirilmesi: Tek Merkez Deneyimi

Amaç: Çocukluk çağında malign karaciğer tümörleri nadirdir. Hepatoblastom ve hepatoselüler karsinom en sık görülen iki tiptir. Bu çalışma ile; kliniğimizde izlenen malign karaciğer tümörü tanısı alan hastalarımızın demografik, klinik özelliklerini ve tedavi sonuçlarını geriye dönük olarak incelemeyi amaçladık. Gereç ve Yöntem: Sağlık Bilimleri Üniversitesi, Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim Araştırma Hastanesi, Çocuk Onkoloji Kliniği’nde 2010-2019 tarihleri arasında takip edilen, karaciğerde malign tümörü olan 13 olgunun demografik özellikleri, tümör lokalizasyonu, klinik ve radyolojik bulguları, histopatolojik bulguları, tedavileri ve son durumları retrospektif olarak incelendi. Bulgular: Karaciğerde malign tümörü olan 13 çocuk hasta (erkek/kız: 6/7) değerlendirildi. Hastaların ortanca yaşı 38 ay (minimum: 4- maksimum: 198 ay) olarak hesaplandı. Hepatoblastom (n=11, %84,6), hepatoselüler karsinom (n=1, %7,69), karaciğerin farklılaşmamış sarkomu (n=1, %7,69) tanıları alan hastalar mevcuttu. Hepatoblastom tanılı 1 hastada (%9) ve undiferansiye sarkom tanılı hastada alfa fetoprotein düzeyi (AFP)

Evaluation of Malignant Liver Tumors in Pediatric Patients: A Single Center Experience

Objectives: Malignant liver tumors are rare in childhood. Hepatoblastoma and hepatocellular carcinoma are the two most common types of malignant liver tumors. In our study, we reviewed the demographic, clinical features and treatment outcomes of pediatric patients with malignant liver mass followed in our clinic retrospectively. Materials and Methods: Patients with 13 malignant liver tumors, who were diagnosed in University of Health Sciences Turkey, Ankara Pediatric Hematology Oncology Training and Research Hospital, Pediatric Oncology Clinic between 2010 and 2019, were included in the study. Their files were reviewed retrospectively, and their demographic characteristics, tumor localization, clinical and radiological findings, treatments and response to treatment were also investigated. Results: Thirteen pediatric patients (male/female: 6/7) with malignant tumors in the liver were evaluated. The median age of the patients was calculated as 38 months (minimum: 4- maximum: 198 months). There were patients diagnosed with hepatoblastoma (n=11, 84.6%), hepatocellular carcinoma (n=1, 7.69%), and liver undifferentiated sarcoma (n=1, 7.69%). Alpha fetoprotein level was

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