Artmış Galektin-3 Düzeyleri, ST Elevasyonlu Miyokart Enfarktüsünü Takiben Gelişen Ventriküler Aritmik Olayları Öngörür

Amaç: Sol ventrikül ejeksiyon fraksiyonu (EF) (LVEF) >%35 ve tek damar tıkanıklığı olan ve primer perkütan koroner girişim (pPCI) ile tedavi edilen ST segment elevasyonlu miyokart enfarktüsü (MI) (STEMI) hastalarında, Galektin-3 (Gal-3) düzeyleri ile mikrovolt T dalga alternans (MTWA) ve sık prematüre ventriküler kompleksler (PVC) arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve Yöntem: Bu kesitsel çalışmaya toplam 81 hasta dahil edildi. Başvuru anında tüm has talardan Gal-3 düzeyleri için kan örnekleri alındı. Hastalar düşük ve yüksek Gal-3 (sırasıyla ≤ ve > 1,93 ng/dL) gruplarına ayrıldı. Düşük Gal-3 ve yüksek Gal-3 grupları hem MTWA hem de PVC pozitifliği açısından karşılaştırılmış ve Gal-3 düzeyleri ile ilişkisi incelenmiştir. Bulgular: Düşük Gal-3 grubu ile karşılaştırıldığında, yüksek Gal-3 hastalarında sol atriyal hacim (LAV) daha yüksekti (55,7±18,0’a karşı 40,6±13,7 mL, p%35 olan tek damarlı STE-MI hastalarında aritmik olayların bir prediktörü idi.

Increased Galectin-3 Levels Predicts Ventricular Arrhythmic Events Following ST-elevation Myocardial İnfarction

Objectives: We aimed to determine the association between Galectin-3 (Gal-3) levels and microvolt T-wave alternans (MTWA) and frequentpremature ventricular complexes (PVCs) in single-vessel patients with left ventricular ejection fraction (EF) (LVEF) >35%, who presented with STelevated myocardial infarction (MI) (STEMI) and were treated with primary percutane-ous coronary intervention (pPCI).Materials and Methods: A total of 81 patients were included in this cross-sectional study. Blood samples for Gal-3 levels were obtained from allpatients at the time of admission. The patients were separated into low and high Gal-3 (≤ and >1.93 ng/dL, respectively) groups. Low-Gal-3 andhigh-Gal-3 groups were compared with respect to both MTWA and PVC positivity and their association with Gal-3 levels were examined.Results: When compared to the low-Gal-3 group, left atrial volume (LAV) was higher in the high-Gal-3 patients (55.7±18.0 vs 40.6±13.7 mL,p35%.

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