Duygu KANKAYA, Fırat ORTAÇ, Arzu ENSARİ, Korhan KAHRAMAN

Over Sertoliform Endometrioid Adenokarsinomu: Tanisal Tuzak Oluşturan Nadir Bir Varyant

Sertoliform endometrioid karsinoma (SEK), endometrioid adenokarsinomanÖn nadir görülen bir varyantÖ olup, seks kord stromal tümöre morfolojik benzerlikleri nedeniyle tanÖsal tuzak oluLturur. Burada, neredeyse tamamÖ seks kord benzeri alanlardan oluLan ve baLlangÖçta sertoli hücreli tümör olarak düLünülen over SEK'sÖna ait bir olgu sunulmuLtur. Sertoli hücreli tümör ile uyumlu olmayan immunohistokimyasal özellikler uyarÖcÖ olmuL ve makroskopik olarak çok geniL örnekleme yapÖlmÖLtÖr, Fokal bir komponent olarak anastomozlaLan kribriform alanlar meydana getiren daha kolumnar özellikte hücrelerle karakterli klasik endometrioid karsinoma alanlarÖnÖn saptanmasÖ üzerine olgu sertoliform endometrioid adenokarsinoma olarak raporlanmÖLtÖr. Bu antitenin tüm patologlar ve jinekolojik onkologlar tarafÖndan akÖlda tutulmasÖ gerekir. Bu tümörlerde do?ru tanÖya ulaLÖlabilmesi ve dolayÖsÖyla hastalarÖn yanlÖL tedavilerden korunabilmesi açÖsÖndan, geniL makroskopik örneklemeyle inceleme yapÖlmasÖ ve geniL bir antikor paneliyle immunohistokimyasal do?rulama çok önemlidir

Ovarian Sertoliform Endometrioid Adenocarcinoma: A Rare Variant Which Causes Diagnostic Pitfalls

Sertoliform endometrioid carcinoma (SEC) is a rare variant of endometrioid adenocarcinoma, which causes diagnostic pitfalls due to its morphologic resemblance of sex cord stromal tumors. Herein, we report a case of SEC in the ovary almost all of which consisted of sex-cord like areas and was presumed to be a sertoli cell tumour initially. Immunohistochemical features incompatible with sertoli cell tumour were alerting and extensive sampling revealed a focal component of classical endometrioid carcinoma with anastomosing cribriform areas of more columnar cells. The final diagnosis was sertoliform endometrioid adenocarcinoma. This entity should be kept in mind for all the pathologists and gynaecologic oncologists. Sampling such tumours extensively and confirming the diagnosis by immunohistochemistry using a large antibody panel is requisite for the correct diagnosis and preventing the patient from inappropriate therapies.

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