Metehan ÇİÇEK, İrem KAR, Abdullah ARSLAN, Dilek ERDİNLİ, Selin KURT, Sertaç ÜSTÜN, Yağmur EKEBİL, Erdeniz ERİŞ, Sena KESİK

Kısa Süreli Bellek Başarısının Kan Glukoz Değeriyle İlişkisi

Amaç: Sunulan çalışmada açlık kan glukozu normal sınırlar içerisinde olan sağlıklı genç erişkin bireylerden oluşan katılımcı grubunda, bilişselişlevlerin kan glukozu seviyeleri ile ilişkisinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Araştırma, Şubat-Haziran 2018 tarihlerinde Ankara Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Nörofizyoloji Laboratuvarı’ndagerçekleştirilmiştir. Belirlenen kriterlere uygun gönüllü katılımcılar en az sekiz saatlik açlık ile davranış testlerine katılmak üzere çağırılmışlardır.Testlerin uygulanmasının öncesinde ve sonrasında her bir katılımcının kan glukoz değerleri One Touch elektronik şeker ölçüm cihazıyla ölçülmüştür.Katılımcıların, bilişsel işlevlerini ölçen davranış testlerindeki doğruluk yüzdeleri ve reaksiyon zamanı bilgileri toplanmıştır. Veriler SPSS 11.5programında değerlendirilmiştir.Bulgular: Katılımcıların davranış deneyleri sonrasında ölçülen kan glukoz değerleriyle ilk ölçülen kan glukoz değerleri arasındaki fark, N-Geritestinde doğru sayısıyla negatif korelasyon göstermiştir (r=-0,238, p

The Relationship Between Short-term Memory And Fasting Blood Glucose

Objectives: This study aimed to correlate cognitive functions with fasting blood glucose through cognitive tests in young adults whose fasting blood glucose within the normal range. Materials and Methods: Study accomplished in Ankara University School of Medicine Department of Physiology, Neurophysiology laboratory in February-June 2018. Subjects who are hungry at least for 8 hours before cognitive testsand match the criteria involved in the study. Blood glucose values were measured before and after tests with One Touch blood glucose meter. Subjects’ reaction times and correct answer rates have collected. The outcomes have evaluated with SPSS 11.5 program. Results: The difference between blood glucose levels after and before the cognitive tests were correlated negatively with correct answer ratios in N-Back test (r=-0.238, p

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1. Tortora GJ & Grabowski SR (2003) Principles of Anatomy and Physiology, 10th ed. San Diego, USA: John Wiley and Sons Inc.
2. Smith C., Marks A., Lieberman M., Marks. Temel Tıbbi Biyokimyası Klinik Yaklaşım (M.Erden İnal, U. Atik, N. Aksoy, A. Haşimi, Çev), 2. baskı, 2007, 3.bölüm, sf.31.
3. T.C. Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu. Erişkin Diyabetli Bireyler İçin Eğitimci Rehberi. 2015; sf.4.
4. Umegaki H. Type 2 Diabetes as A Risk Factor For Cognitive Impairment: Current Insights, Dovepress J: Clinical Interventions in Aging, 2014 June, 1011-1019.
5. Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, et al. Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med. 2005;353:1454-62.
6. Wright SR, Levy SA, Katzel LI, Rosenberger WF, Manukyan Z, Whitfield KE, et al. Fasting glucose and glucose tolerance as potential predictors of neurocognitive function among nondiabetic older adults. J Clin Exp Neuropsychol. 2015;37:49-60.
7. Shaye K, Amir T, Shlomo S, Yechezkel S. Fasting Glucose Levels Within the High Normal Range Predict Cardiovascular Outcome, Am Heart J. 2012;164:111-6.
8. Simons LA, Friedlander Y, McCallum J, Simons J. Fasting plasma glucose in non-diabetic elderly women predicts increased all-causes mortality and coronary heart disease risk. Aust N Z J Med. 2000;30:41-7.
9. Mortby ME, Janke AL, Anstey KJ, Sachdev PS, Cherbuin N. High “normal” blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study. PLoS One. 2013;8:e73697.
10. Zhang T, Shaw M, Humphries J, et al. Higher fasting plasma glucose is associated with striatal and hippocampal shape differences: the 2sweet project. BMJ Open Diabetes Res Care. 2016;4:e000175.
11. Convit A, Wolf OT, Tarshish C, de Leon MJ. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci U S A. 2003;100:2019-22.
12. Casey BJ, Tottenham N, Liston C, Durston S. Imaging the developing brain: what have we learned about cognitive development? Trends Cogn Sci. 2005;9:104-10.
13. Kerti L, Witte A. V, Winkler A, et al. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology. 2013;81:1746-52.
14. https://en.oxforddictionaries.com/definition/cognition 15.12.2017 tarihinde erişilmiştir.
15. Bear M. F, Connors B. W, Paradiso M A. Neuroscience: Exploring the Brain, 3rd edition, Lipincott Williams & Wilkins.
16. Mattson MP. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab. 2012;16:706-22.
17. Zhang T, Shaw M, Walsh E, et al. Higher fasting plasma glucose is associated with smaller striatal volume and poorer fine motor skills in a longitudinal cohort. Psychiatry Res Neuroimaging. 2018;278:1-6.
18. Mueller, ST. The Psychology Experiment Building Language 2013, (Version 0.13) [Software]. Available from http://pebl.sourceforge.net.
19. Ebbinghaus H. Memory. A Contribution to Experimental Psychology. New York: Teachers College, Columbia University; 1913.
20. Bear M. F, Connors B. W, Paradiso M A. Neuroscience: Exploring the Brain, 3rd edition, Lipincott Williams&Wilkins.
21. Gailliot MT, Baumeister RF. The physiology of willpower: Linking Blood Glucose to Self Control, Pers Soc Physcol Rev, 2007;11:303
22. Scholey AB, Harper S, Kennedy DO. Cognitive demand and blood glucose. Physiol Behav. 2001;73:585-92.
23. Riby LM, Mclaughlin J, Riby DM et al. Lifestyle, glucose regulation and the cognitive effects of glucose load in middle-aged adults. Br J Nutr. 2008;100:1128-34.
24. Dunn-Meynell AA, Sanders NM, Compton D, et al. Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci. 2009;29:7015-22.
25. Lieberman HR, Caruso CM, Niro PJ, et al. A double-blind, placebo-controlled test of 2 d of calorie deprivation: effects on cognition, activity, sleep, and interstitial glucose concentrations. Am J Clin Nutr. 2008;88:667-76.