Malign Plevral Mezotelyoma Yönetimi

Malign mezotelyoma (MM); plevra, periton, tunika vaginalis veya perikardın mezotelyal yüzeylerinden köken alan, kötü prognoza sahip, nadir birmalignitedir. Malign plevral mezotelyoma (MPM), MM’nin en sık görülen tipidir ve plevral yaprakların mezotelyal yüzeylerinden gelişir. Tanı genellikleileri evrede konulabildiğinden tedavisi zor kanserlerdir. MPM’de ortanca sağkalım 6 ile 18 ay arasındadır. Bununla birlikte, lokalize hastalığı olanlardamultimodaliter tedavi ile uzun süreli sağkalım sağlanabileceğine dair veriler vardır. Bu derlemede MPM‘de sağkalımı iyileştirmek için yapılan cerrahi,radyoterapi, kemoterapi, hedefe yönelik tedavi ve immünoterapi çalışmalarının sonuçlarının değerlendirilmesi amaçlanmıştır.

Management of Malignant Pleural Mesothelioma

Malignant mesothelioma (MM) arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium. MM is a rare and insidious neoplasm with a poor prognosis. Malignant pleural mesothelioma (MPM) is the most common type and typically arises from the mesothelial surfaces of the pleural cavity. MPM can be difficult to treat because most patients have advanced disease at presentation. The median survival of patients is between 6 and 18 months. However, carefully selected patients with localized disease who receive aggressive multimodality therapy have relatively prolonged survival. In this review, we aimed to evaluate the results of surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy studies to improve survival in MPM.

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