Neslihan ÖZYURT, Mustafa GÜRBÜZ, Güngör UTKAN

Kaposi Sarkomu ve Myelodisplastik Sendromu Birlikteliği Olan Nadir Bir Olgu

Kaposi sarkomu (KS), human herpes virüs 8 (HHV-8) ile ilişkili anjiyoproliferatif bir hastalıktır. KS’nin klasik, endemik, posttransplant ve epidemik olmak üzere dört çeşidi vardır. Klasik KS erkekleri kadınlardan daha çok etkiler ve bildirilen erkek-kadın oranı yaklaşık 3: 1’dir. KS’nin patch, plak ve nodüler olmak üzere üç histolojik evresi vardır. Miyelodisplastik sendrom (MDS), displaz, inefektif eritropoez ve akut lösemiye dönüşüm ile karakterize, heterojen malign hematopoyetik kök hücre bozukluğudur. Bildiğimiz kadarıyla literatürde 2 tane KS ve MDS birlikteliği olan olgu bildirilmiştir. Bizde takip ettiğimiz KS ve MDS birlikteliği olan bir hastanın tedavisini güncel literatür eşliğinde tartışmak istedik.

Patient with Kaposi Sarcoma and Myelodysplastic Syndrome

Kaposi sarcoma (KS) is an angioproliferative disorder that requires infection with human herpes virus 8 (HHV-8). KS is classified into four types:classic, endemic, posttransplantation and epidemic. Classic Kaposi sarcoma (CKS) affects men more often than women; the reported male to female ratio is approximately 3:1. KS has three histological stages: patch, plaque and nodular. The myelodysplastic syndromes (MDS) comprise a heterogeneous group of malignant hematopoietic stem cell disorders characterized by dysplastic and ineffective blood cell production and a variable risk of transformation to acute leukemia. In literature data, we could cite only two report that described KS and MDS. We aimed to discuss the treatment of a patient with CS and MDS.

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