Böbrek Malignitelerini Karakterizasyon ve Derecelemede Bilgisayarlı Tomografi Ne Kadar Yetkin: Bizim Deneyimimiz
Giriş: Uygun tedavi ve mümkün olan en uzun sağkalım için böbrek tümörlerinde doğru tanı kritik önem taşır. Bu çalışmanın amacı böbrek kitlelerinde benign-malign ayrımı ve doğru dereceleme için bilgisayarlı tomografi (BT) parametrelerinin ayrıntılı incelenmesidir. Gereç ve Yöntem: Çalışmaya 2006-2011 yılları arasında ünitemizde multifazik BT incelemesi gerçekleştirilmiş 53 hasta dahil edilmiştir. Prekontrast, kortikomedüller ve nefrografik faz görüntülerinde kitle, normal parankim ve abdominal aorta kontrastlanma dereceleri ile lezyonların görüntüleme bulguları, retrospektif ve cerrahi sonuçlara kör olarak değerlendirilmiştir. İstatistiksel analizde bağımsız gruplarda kategorik değişkenler için kikare, ölçülebilir değişkenler için Mann-Whitney U testi, kullanılmış, renal tümör tiplerini ayırmada alıcı işletim karakteristiği eğirisi analizleri gerçekleştirilmiştir, uygun parametrelerde eşik değer belirlemede “Youden” indeksi hesaplanmıştır. p
How Competent is Computed Tomography in Characterization and Grading of Renal Malignancies: Our Experience
Objectives: Accurate diagnosis of renal tumors is critical for obtaining the best treatment and longest possible survival. The purpose of this study is to evaluate computed tomography (CT) parameters of renal masses in order to assess benign and malignant nature as well as accurate grading. Materials and Methods: Fifty three cases with multiphasic abdominal CTs between 2006 and 2011 were included. Precontrast, corticomedullary, nephrographic postcontrast phase images were retrospectively examined for lesion characteristics, enhancement degrees with regard to the normal renal parenchyma and abdominal aorta, blinded to the surgical results. To compare independent groups for categorical variables chi-square, for metric variables Mann-Whitney U tests were used. Receiver operating characteristics curve analysis was performed to group renal tumor subtypes and when applicable the cut-off values were determined, “Youden” index was calculated. p
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- Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med.
1996;335:865-875.
- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin.
2015;65:5-29.
- Gore ME, Larkin JM. Challenges and opportunities for converting renal
cell carcinoma into a chronic disease with targeted therapies. Br J Cancer.
2011;104:399-406.
- Chow WH, Devesa SS, Warren JL, Fraumeni JF. Rising incidence of renal cell
cancer in the United States. JAMA. 1999;281:1628-1631.
- Shinagare AB, Krajewski KM, Braschi-Amirfarzan M, et al. Advanced Renal
Cell Carcinoma: Role of the Radiologist in the Era of Precision Medicine.
Radiology. 2017;284:333-351.
- Siegel CL, McFarland EG, Brink JA, et al. CT of cystic renal masses: analysis of
diagnostic performance and interobserver variation. AJR Am J Roentgenol.
1997;169:813-818.
- Israel GM, Bosniak MA. How I do it: evaluating renal masses. Radiology.
2005;236:441-450.
- Bird VG, Kanagarajah P, Morillo G, et al. Differentiation of oncocytoma and
renal cell carcinoma in small renal masses (<4 cm): the role of 4-phase
computerized tomography. World J Urol. 2011;29:787-792.
- Lughezzani G, Jeldres C, Isbarn H, et al. Tumor size is a determinant of
the rate of stage T1 renal cell cancer synchronous metastasis. J Urol.
2009;182:1287-1293.
- Birnbaum BA, Jacobs JE, Ramchandani P. Multiphasic renal CT: comparison
of renal mass enhancement during the corticomedullary and nephrographic
phases. Radiology. 1996;200:753-758.
- Kovacs G, Akhtar M, Beckwith BJ, et al. The Heidelberg classification of renal
cell tumours. J Pathol. 1997;183:131-133.
- Truong LD, Shen SS. Immunohistochemical diagnosis of renal neoplasms.
Arch Pathol Lab Med. 2011;135:92-109.
- Pathology and Genetics of Tumours of the Urinary System and Male Genital
Organs (IARC WHO Classification of Tumours) Lyon: IARC Press; 2004.
- Tirumani SH, Souza D, Krajewski KM, et al. Impact of histologic subtype and
sarcomatoid transformation on metastasis in renal cell carcinoma: a single
institute experience in 149 patients. Abdom Radiol (NY). 2016;41:295-302.
- Zhang J, Lefkowitz RA, Ishill NM, et al. Solid renal cortical tumors:
differentiation with CT. Radiology. 2007;244:494-504.
- Sheir KZ, El-Azab M, Mosbah A, et al. Differentiation of renal cell carcinoma
subtypes by multislice computerized tomography. J Urol. 2005;174:451-
455.
- Garant M, Bonaldi VM, Taourel P, et al. Enhancement patterns of renal
masses during multiphase helical CT acquisitions. Abdom Imaging.
1998;23:431-436.
- Ruppert-Kohlmayr AJ, Uggowitzer M, et al. Differentiation of renal
clear cell carcinoma and renal papillary carcinoma using quantitative CT
enhancement parameters. AJR Am J Roentgenol. 2004;183:1387-1391.
- Young JR, Margolis D, Sauk S, et al. Clear cell renal cell carcinoma:
discrimination from other renal cell carcinoma subtypes and oncocytoma
at multiphasic multidetector CT. Radiology. 2013;267:444-453.
- Kim JK, Kim TK, Ahn HJ, et al. Differentiation of subtypes of renal cell
carcinoma on helical CT scans. AJR Am J Roentgenol. 2002;178:1499-506.