Combined tubal and ovarian ectopic pregnancies in one patient after in vitro fertilization

İntrasitoplazmik sperm enjeksiyonu-embryo transferi siklusundan sonra aynı tarafta gelişen ovaryan- tubal ikiz ektopik gebelik olgusu bildirilmiştir. Vaka, alt kadranlarda karın ağrısı şikayeti ile, 3 embryo transferinden 27 gün sonra ektopik gebelik şüphesi ile kliniğimize refere edildi. Transvajinal ultrasonografide sol adneksiyal alanda içerisinde yolk kesesi bulunan 17 mm gestasyonel kese ve 15 mm eko-kompleks ovaryan kitle tesbit edildi. Laparotomide, sol adnekste 2 cm rüptüre hemorajik ovaryan kitle ve 2 cm intakt fimbrial ektopik gebelik ile uyumlu kitle görüldü. Sol parsiyel salfenjektomi ve sol overe wedge rezeksiyon yapıldı. Histopatoloji incelemede hem over dokusunda hem de fallopi tüpünde koryonik villusların varlığı gösterildi.

İn vitro fertilizasyondan sonra aynı hastada kombine tübal ve ovaryan ektopik gebelikler

A case of twin ectopic ovarian-tubal pregnancy located at the same side after an intracytoplasmic sperm injection-embryo transfer cycle is reported. The case was refered to our clinic for suspected ectopic pregnancy 27 days later the transfer of 3 embryos, with lower abdominal pain. Transvaginal ultrasound scan revealed 17 mm gestational sac with a yolk sac inside and a 15 mm echocomplex ovarian mass at the left adnexa. At laparotomy a ruptured 2 cm ovarian hemorrhagic mass and an unruptured 2 cm fimbrial ectopic pregnancy was found at the left adnexa. A left partial salphengectomy and wedge resection of the left ovary was performed. The histopathology showed the presence of chorionic villi both in the ovarian tissue and the left fallopian tube.

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  • 1. Hage PS, Arnouk IF, Zarou DM, Kim BH, Wehbeh HA. Laparoscopic management of ovarian ectopic pregnancy. J Am Assoc Gynecol Laparosc. 1994 May;1(3):283-5. Review.
  • 2. Abusheikha N, Salha O, Brinsden P. Extrauterine pregnancy following assisted conception treatment. Hum Reprod Update. 2000 Jan-Feb;6(1):80-92. Review.
  • 3. Marcus SF, Brinsden PR. Primary ovarian pregnancy after in vitro fertilization and embryo transfer: report of seven cases. Fertil Steril. 1993 Jul;60(1):167-9.
  • 4. De Ott. A case of unilateral tubal twin gestation. Ann Gynecol Obstet 1891;36:304.
  • 5. Ansari SM, Nessa L, Saha SK. Twin ectopic pregnancy 10 years after permanent sterilization. Australas Radiol. 2000 Feb;44(1):107- 8.
  • 6. Deshpande N, Mathers A, Acharya U. Broad ligament twin pregnancy following in-vitro fertilization. Hum Reprod. 1999 Mar;14(3):852-4.
  • 7. Hanchate V, Garg A, Sheth R, Rao J, Jadhav PJ, Karayil D. Transvaginal sonographic diagnosis of live monochorionic twin ectopic pregnancy. J Clin Ultrasound. 2002 Jan;30(1):52-6.
  • 8. Parker J, Hewson AD, Calder-Mason T, Lai J. Transvaginal ultrasound diagnosis of a live twin tubal ectopic pregnancy. Australas Radiol. 1999 Feb;43(1):95-7.
  • 9. Marret H, Hamamah S, Alonso AM, Pierre F. Case report and review of the literature: primary twin ovarian pregnancy. Hum Reprod. 1997 Aug;12(8):1813-5. Review.
  • 10.Karande VC, Flood JT, Heard N, Veeck L, Muasher SJ. Analysis of ectopic pregnancies resulting from in-vitro fertilization and embryo transfer. Hum Reprod. 1991 Mar; 6(3): 446-9.
  • 11.Einenkel J, Baier D, Horn LC, Alexander H. Laparoscopic therapy of an intact primary ovarian pregnancy with ovarian hyperstimulation syndrome: case report. Hum Reprod. 2000 Sep;15(9):2037-40.
  • 12.Ophir E, Singer-Jordan J, Oettinger M, Odeh M, Tendler R, Feldman Y, Fait V, Bornstein J. Uterine artery embolization for management of interstitial twin ectopic pregnancy: case report. Hum Reprod. 2004 Aug;19(8):1774-7. Epub 2004 Jun 24.
  • 13.Sandvei R, Ulstein M. History and findings in ectopic pregnancies in women with and without an IUD. Contracept Deliv Syst. 1980 Apr;1(2):131-8.
  • 14.Oliveira FG, Abdelmassih V, Costa AL, Balmaceda JP, Abdelmassih S, Abdelmassih R. Rare association of ovarian implantation site for patients with heterotopic and with primary ectopic pregnancies after ICSI and blastocyst transfer. Hum Reprod. 2001 Oct;16(10):2227-9.
  • 15.Gaudoin MR, Coulter KL, Robins AM, Verghese A, Hanretty KP. Is the incidence of ovarian ectopic pregnancy increasing? Eur J Obstet Gynecol Reprod Biol. 1996 Dec 27;70(2):141-3.
  • 16.Tal J, Haddad S, Gordon N, Timor-Tritsch I. Heterotopic pregnancy after ovulation induction and assisted reproductive technologies: a literature review from 1971 to 1993. Fertil Steril. 1996 Jul;66(1):1-12.
  • 17.Atabekoglu CS, Berker B, Dunder I. Ovarian ectopic pregnancy after intracytoplasmic sperm injection. Eur J Obstet Gynecol Reprod Biol. 2004 Jan 15;112(1):104-6.
  • 18.Yovich JL, Turner SR, Murphy AJ. Embryo transfer technique as a cause of ectopic pregnancies in in vitro fertilization. Fertil Steril. 1985 Sep;44(3):318-21.
  • 19.Hemmings R, Biljan MM, Dean N, Tan SL. An ectopic pregnancy masked by follicular initiation of gonadotropin-releasing hormone agonist for pituitary desensitization prior to in vitro fertilization. J Assist Reprod Genet. 1998 Mar;15(3):161-3.
  • 20.de Crespigny LC. Demonstration of ectopic pregnancy by transvaginal ultrasound. Br J Obstet Gynaecol. 1988 Dec;95(12):1253-6.
  • 21.Stabile I, Campbell S, Grudzinskas JG.Can ultrasound reliably diagnose ectopic pregnancy? Br J Obstet Gynaecol. 1988 Dec;95(12):1247-52.
  • 22.Comstock C, Huston K, Lee W. The ultrasonographic appearance of ovarian ectopic pregnancies. Obstet Gynecol. 2005 Jan;105(1):42-5.
  • 23.Raziel A, Golan A, Pansky M, Ron-El R, Bukovsky I, Caspi E. Ovarian pregnancy: a report of twenty cases in one institution. Am J Obstet Gynecol. 1990 Oct;163(4 Pt 1):1182-5.
  • 24.Hallatt JG. Primary ovarian pregnancy: a report of twenty-five cases. Am J Obstet Gynecol. 1982 May 1;143(1):55-60.
  • 25.Ranieri DM, Sturdy J, Marchant S, Kinis A, Serhal P. Ovarian heterotopic pregnancy after IVF and contralateral tubal ectopic pregnancy after GIFT. Acta Eur Fertil. 1992 Sep- Oct;23(5):243-5
  • 26.Seinera P, Di Gregorio A, Arisio R, Decko A, Crana F. Ovarian pregnancy and operative laparoscopy: report of eight cases. Hum Reprod. 1997 Mar;12(3):608-10
  • 27.Annunziata N, Malignino E, Zarcone R. Ovarian pregnancies treated with methotrexate. Panminerva Med. 1996 Sep;38(3):190-2