Gürbüz ERDOĞAN, Murat Faik ERDOĞAN, Mutlu ARAT, Bilge CEYDİLEK, Hamdi AKAN

Allojenik hematopoietik hücre naklinde gözlenen tiroid fonksiyon bozuklukları

Amaç: Allojeneik hematopoietik hücre nakli (AHHN) sırasında kullanılan yüksek doz kemoterapi ve/veya tüm vücut ışınlama yöntemi tiroid fonksiyonlarında değişikliklere neden olabilmektedir. Bu çalışma, AHHN uygulanan hastalarda nakil sonrası dönemde gelişebilecek tiroid fonksiyon bozukluklarını tanımlamak amacıyla yapıldı. Gereç ve Yöntem: Ortalama takip süresi 16 ay (1-38 ay) olan 68 olgu retrospektif olarak incelendi. Bulgular ve Sonuç: Nakil sonrası ilk altı ay içerisinde üç hastada antikor negatif tirotoksikoz geliştiği görüldü. Bunların ikisi düşük, biri ise yüksek uptakeliydi.

Thyroid dysfunction after allogeneic hematopoietic stem cell transplantation

Purpose: High dose chemotherapy and total body irradiation during allogeneic hematopoietic stem cell transplantation (AHCT) may cause changes on thyroid functions. This study aims to define thyroid dysfunction may occur during posttransplant period. Materials and Methods: 68 cases with a median follow-up time of 16 months were examined retrospectively. Results and Conclusion: It is observed that three patients have developed antibody negative thyrotoxicosis in first six mounts of the posttransplant period. Two of these patients were associeted with a low uptake an one of them was with a high uptake.

PDF

___

1. Vexiau P, Castiglioni PP. The euthyroid sick sendrome incidence, risk factors and prognostic value soon after allogeneic bone marrow transplantation. British Journal of Haematology 1993; 85:778-782. 2. Tauchmanova L, Selleri C. High prevalence of endocrine dysfunction in long term survivors after allogeneic bone marrow transplantation for haematologyc diseases. Cancer 2002; 95:1076-84. 3. Toubert ME, Socie G, Gluckman E. Short and long term follow up of thyroid dysfunction after allogeneic bone marrow transplantation without the use of preparative total body irradiation. Br. J. Haematol. 1997; 98:453. 4. Sklar CA, Kim TH, Ramsay NK. Thyroid dysfunction among long term survivors of bone marrow transplantation. Am. J. Med. 1982; 73:688. 5. Serafino L, William A. Thyroid and pituitary function followig allogeneic bone marrow transplantation. Arch. Intern. Med. 1988; 148:1066-1071. 6. Kami M, Tanaka Y. Thyroid function after bone marrow transplantation: possible association between immune-mediated thyrotoxicosis and hypothyroidism. Transplantation. 2001; 71:406-411. 7. Mulligan SP, Joshua DE, Joasoo A et al. Autoimmune hyperthyroidism associated with chronic graft versus host disease. Transplantation. 1987; 44:463.