Enis MACİT, Şahan SAYGI, Hüsamettin GÜL, Levent YAMANEL

Suicide attempts with tricyclic antidepressants

Trisiklik antidepresanlar (TCA) analjeziklerden sonra en yaygın kullanılan ve sıklıkla akut zehirlenmelere neden olan ilaçlardır. Bu çalışmada üç intihar amaçlı zehirlenme vakasında hastaların idrar ve kan örneklerinde toksikolojik tarama testleri GC/MS ve FPIA metodları ile yapıldı. Birinci vakada ilk gün amitriptilin, asetaminofen ve kodein seviyesi sırasıyla 1135 ng/ml serum, 14.42 ng/ml serum ve 72.9 ng/ml idrar,takibeden üç günde ise amitriptilin düzeyi 505, 429 ve 370 ng/ml serum olarak ölçüldü. İkinci vakada,1. ve 2. gün amitriptilin seviyesi 883.56 ve 137.35 ng/ml serum olarak, üçüncü vakada ise imipramin düzeyi 2560 ng/ml serum olarak ölçüldü. Birinci ve ikinci vakalar 4 gün içerisinde tamamen iyileşirken üçüncü hasta 36 saat sonra hayatını kaybetti. Akut zehirlenmelerde acil tedavinin erken ve toksikolojik analizlerin de güvenilir ve hızlı yapılmasının hayati derecede önemli olduğu gösterilmiştir.

Trisiklik antidepresanlarla intihar girişimleri

Tricyclic antidepressant drugs (TCA) are the second widely used drugs after the analgesics, and involve in acute poisoning cases. In this study we measured unusual high dose of TCA levels in three suicidal poisoning cases. Toxicological screening on patients urine and blood samples were performed with GC/MS, and the quantitation of drugs were done with GC/MS and FPIA methods. Amitriptyline, acetaminophen, and codeine levels were 1135 ng/ml blood, 14.42 (ig/ml blood, and 72.9 ig/ml urine respectively in case 1. Amitriptyline levels were found as 505, 429, and 370 ng/ml blood for consequent three days. In Case 2, amitriptyline levels were 883.56 and 137.35ng/ml blood for two days. In Case 3, initial imipramine level was 2560 ng/ml blood. First two patients were fully recovered 4 days after the incident. The third patient died 36 hours after the admission. In acute poisoning cases, early emergency teratment, obtaining rapid and reliable toxicological laboratory results were considered vitally important in poisoning cases.

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Ankara Üniversitesi Eczacılık Fakültesi Dergisi-Cover

ISSN: 1015-3918
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2016
Yayıncı: Ankara Üniversitesi Eczacılık Fakültesi

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