OKSİDATİF STRES VE PARKİNSON HASTALIĞI

Amaç: Parkinson Hastalığı (PH) beyinde dopaminerjik nöronların kaybıyla ilişkili kronik ve progresif nörodejeneratif bir hastalıktır. Yaşlılık tüm nörodejeneratif hastalıklarda olduğu gibi PH’nın oluşumunda da kanıtlanmış tek faktördür. Yaşlılıkta daha fazla tetiklenen oksidatif stresin dopaminerjik nörotoksisite oluşumunda önemli bir rol oynadığı düşünülmektedir. Bu derlemede oksidatif stres ve PH arasındaki ilişki irdelenecektir. Gereç ve Yöntem: PH ile oksidatif stres arasındaki ilişkinin tespiti için yapılmış çalışmaların kapsamlı olarak derlenebilmesi için sağlık bilimleri alanındaki veri tabanları kullanılmıştır. Web of Science gibi temel atıf indekslerinde daha önce yayımlanmış makalelerden yararlanılmıştır. Sonuç ve Tartışma: Parkinson çok sayıda temel hücresel süreci etkileyen genetik ve çevresel faktörlerin kompleks etkileşiminden kaynaklanan nörodejeneratif bir hastalıktır. Oksidatif stres genetik bütünlüğü tehdit eder ve PH’nın gelişimine katkı sağlar. Oksidatif strese bağlı olarak meydana gelen hasar ürünlerinden kaçınmak ve bu çizgide koruyucu tedavi protokolü çizmek sağlıklı beyin fonksiyonlarının devamı ve organizmayı Parkinson gibi nörodejeneratif hastalıklardan korumak adına önemli bir strateji olabilir.

OXIDATIVE STRESS AND PARKINSON DISEASE

Objective: Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disease in the brain associated with the loss of dopaminergic neurons. Old age is the only proven factor in the development of PD. It is thought that oxidative stress which is more triggered in old age plays a vital role in the formation of dopaminergic neurotoxicity. In this review, the relationship between oxidative stress and PD will be examined. Material and Method: The databases in the health sciences field were used to compile the studies conducted to determine the relationship between PH and oxidative stress. Previously published articles such as Web of Science have been used. Result and Discussion: Parkinson's is a neurodegenerative disease resulting from the complex interaction of genetic and environmental factors that affect on many basic cellular process. Oxidative stress threatens genetic integrity and contributes to the development of PH. Avoiding damage products due to oxidative stress and drawing a protective treatment protocol may be a crucial strategy for maintaining healthy brain function and protecting the organism from neurodegenerative diseases such as Parkinson's disease.

Keywords:

Parkinson's disease (PD), oxidative stress, reactive oxygen species (ROS) aging, neurodegenerative disease,

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