DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI

Amaç: Deney hayvanlarında bitkisel kaynaklı antioksidanların kullanımının fertilite üzerine etkisini araştırmak amaçlandı. Gereç ve Yöntem: Bu alanda yapılmış bilimsel çalışmalar incelendi. Elde edilen bilimsel bilgiler doğrultusunda antioksidan içerikli bazı bitkilerin deney hayvanlarında fertilite parametrelerine etkileri derlenmeye çalışıldı. Antioksidanlar, oksidasyonu engelleyen maddeler olarak tanımlanmaktadır. En yaygın antioksidan maddeler arasında olan A vitamini, C vitamini, E vitamini ve fenolik bileşiklerin temel kaynağı bitkilerdir. Antioksidan maddeler, hücresel metabolizma ile mitokondrilerde enerji üretilmesi sırasında yan ürün olarak açığa çıkan serbest radikalleri nötraliz ederek zararlı etkilerine karşı vücudu korurlar. Ancak açığa çıkan serbest radikaller antioksidan maddelerin detoksifiye etme kapasitesini aşarsa oksidatif stres meydana gelerek hücrelerde Dezoksiribonükleik asit (DNA), protein ve lipit hasarı ile malignant hücre gelişimine neden olabilir. Dolayısı ile oksidatif stresin organ ve dokularda hastalık meydana getirmesinin yanında eşey hücrelerde oluşturduğu fonksiyon bozuklukları ile de reprodüktif sorunlara yol açmaktadırlar. Sonuç ve Tartışma: Tavşan, sıçan ve fareler üzerinde yapılan çalışmalarda nötralize edilemeyen serbest radikallerin fertilite sorunlarına yol açtığı tespit edilmiştir. Bu alanda yapılan çalışmaların sonucunda deney hayvanlarında bitkisel kaynaklı antioksidanların kullanımın sperm, semen, oosit ve embriyo gibi fertilite parametrelerini iyileştirdiği saptanmıştır.

USES OF PLANT-DERIVED ANTIOXIDANTS IN TERMS OF FERTILITY IN EXPERIMENTAL ANIMALS

Objective: This study was aimed to investigate the effect of using plant-derived antioxidants on fertility in experimental animals. Material and Method: Scientific studies related to this study were investigated. In line with information obtained, the effects of some antioxidant plants on fertility parameters of experimental animals were reviewed. Antioxidants are defined as substances that inhibits oxidation. The most common antioxidant substances are vitamin A, vitamin C, vitamin E and phenolic compounds. And also, their main origin are the plants. Free radicals arise as byproduct during production of energy by cellular metabolism in mitochondria. Antioxidants neutralize free radicals and thus protect the body against the harmful effects of oxidants. If the free radicals exceed detoxification capacity of antioxidant substances, oxidative stress occurs. Oxidative stress can damage to cellular components such as deoxyribonucleic acid (DNA), protein and lipids and leads to formation of malignant cells. So, oxidative stress results in reproductive problems because it induces functional disorders in sex cells, organs and tissues. Result and Discussion: Studies on rabbits, mice, and rats have shown that non-neutralized free radicals cause reproductive dysfunction In conclusion, it was determined that the plant-derived antioxidants improve fertility parameters such as sperm, semen, oocytes and embryos in the experimental animals.

Keywords:

experimental animal, fertility, oxidative stress plant-derived antioxidants,

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