Ufuk ÇALIŞKAN, Gökşen Dilşat DURBİLMEZ, Gökmen MEMİŞ

BENİGN PROSTAT HİPERPLAZİSİ ÜZERİNDE ETKİLİ FİTOTERAPÖTİKLER

Amaç: İyi huylu prostat büyümesi (Benign Prostat Hiperplazisi=BPH), elli yaş üstü erkeklerin ortalama üçte birinde görülen hem idrar depolama, boşaltma ve boşaltma sonrası semptomlara yol açan, hem de olguların yaşam kalitesini bozan bir durumdur. BPH’ye bağlı alt üriner sistem hastalıklarının tedavisinde fitoterapötikler uzun zamandan beri klinik uygulamalarda yer almaktadır. Bu çalışmanın amacı BPH tedavisinde en sık kullanılan fitoterapötikler olan Cucurbita pepo, Epilobium sp., Hypoxis rooperi, Lycopersicon esculentum Mill., Pinus pinaster Aiton, Pygeum africanum, Roystonea regia (Kunth) O.F. Cook, Secale cereale, Serenoa repens, Urtica dioica’nın etkinlikleri ve yapılan önemli klinik çalışmaları derlemektir. Sonuç ve Tartışma: Kanıta dayalı tıp zemininde BPH’ye yönelik alt üriner sistem hastalıklarının tedavisinde fitoterapötiklerin birçok semptomda düzelme sağladığı söylenmekle birlikte çalışmalar daha fazla plasebo kontrollü, çift-kör randomize çalışmalara ihtiyaç duyulduğunu göstermektedir.

EFFECTS OF PHYTOTERAPEUTICS ON BENIGN PROSTATE HYPERPLASIA

Objective: Benign prostatic hyperplasia (BPH) is a condition that causes symptoms during urinary storage, discharge and after discharge, which are seen in an average one third of men over the age of fifty, as well as disrupts the quality of life. Phytotherapeutics have long been involved in clinical practice in the treatment of lower urinary tract symptoms associated with BPH. The goal of this study is to review pharmacological and clinical studies on Cucurbita pepo, Epilobium sp., Hypoxis rooperi, Lycopersicon esculentum Mill., Pinus pinaster Aiton, Pygeum africanum, Roystonea regia (Kunth) O.F. Cook, Secale cereale, Serenoa repens, Urtica dioica, which are the most frequently used plant species in BPH treatment. Result and Discussion: It is argued that phytotherapeutics improve symptoms in the treatment of lower urinary tract for BPH, on the other hand most of the studies shows that more placebo-controlled, double-blind randomization studies involving large patient numbers were needed.

Keywords:

BPH, phytotherapeutic, prostatic disease,

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