Emre Şefik ÇAĞLAR, Gökçe KARAOTMARLI GÜVEN, Neslihan ÜSTÜNDAĞ OKUR

DEKSPANTENOL İÇEREN KARBOPOL ESASLI HİDROJELLERİN HAZIRLANMASI VE KARAKTERİZASYONU

Amaç: Bu çalışmanın amacı, salım modellerini değiştirmek ve piyasa ürününün fizikokimyasal özelliklerini geliştirmek için dekspantenol yüklü hidrojel formülasyonları oluşturmaktır. Gereç ve Yöntem: Hidrojel formülasyonları yapmak için, %1, %1.5 ve %2 (a/a) konsantrasyonlarında Carbopol Ultrez kullanıldı. Aktif bileşen dekspantenol daha sonra formülasyonlara %5 (a/a) oranında ilave edildi. Formülasyonlar için pH, viskozite, doku profili analizi, yayılabilirlik, biyoadezyon ve in vitro salım özelliklerinin tümü değerlendirildi. Sonuç ve Tartışma: Formülasyonların cilt uygulaması için uygun olduğu bulundu. TPA analizi, G1 ve G1-DXP'nin formülasyonların düşük sertlik değerinin sırası ile 10.1851.219 ve 30.8541.637 g sahip olduğunu ortaya koydu. Bu formülasyonların biyoadhezyon mukavemeti, önceki formülasyonlardan daha esnek oldukları ve düşük sertlik değerlerine sahip oldukları için arttı. Geliştirilen formülasyonlar ilk üç saatte %50’nin üzerinde DXP salımı gözlenirken piyasa preparatı %10’un üzerine bile çıkamamıştır. İn vitro salım kinetiği çalışmasında tüm formülasyonların Higuchi modeline uyduğu hesaplanmıştır. Sonuç olarak piyasadaki ürünlere göre daha etkin bir ilaç salım sistemi geliştirilmiştir. Halihazırda hazırlanan formülasyonlar, tedavide kullanımları açısından da umut vadeden formülasyonlardır.

Anahtar Kelimeler:

Dekspantenol, hidrojel, karakterizasyon, karbopol

PREPARATION AND CHARACTERIZATION OF CARBOPOL BASED HYDROGELS CONTAINING DEXPANTHENOL

Objective: The purpose of this study is to create dexpanthenol-loaded hydrogel formulations to alter the release patterns and enhance the physicochemical qualities of the market product. Material and Method: To make hydrogel formulations, Carbopol Ultrez was utilized in concentrations of 1%, 1.5%, and 2% (w/w). The active component dexpanthenol was then added to the formulations at a concentration of 5% (w/w). pH, viscosity, texture profile analysis, spreadability, bioadhesion, and in vitro release characteristics were all assessed for the formulations. Result and Discussion: The formulations were found to be suitable for cutaneous application. TPA analysis revealed that the G1 and G1-DXP formulations had the hardness value 10.1851.219 and 30.8541.637 g, respectively. That formulations’ bioadhesion strength has grown because they are more flexible than previous formulations while having low hardness values. As such, it has been observed that the formulations release more than 50% of DXP in three hours while the market preparation was not even reach the 10% drug release. In the in vitro release kinetics study, it was calculated that all formulations fit the Higuchi model. As a result, a more effective drug delivery system has been developed compared to the market preparation. The currently prepared formulations are also promising formulations in terms of their use in treatment.

Keywords:

Carbopol, characterization, dexpanthenol, hydrogel,

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