Antioxidant activity of N--substituted indole-2 and 3-carboxamides

Bir seri N-sübstitüe indol amid türevinin, sıçan karaciğerinden elde edilen mikrozomal NADP'ye bağımlı lipid peroksidasyon (LP) ve süperoksit anyon şekillenmesi üzerinde olan invitro etkileri test edildi. Vitamin E (a-tokoferol), LP seviyesini W4 M konsantrasyonda yaklaşık % 63 kadar azalttı. Bileşiklerden 1,8 ve 10'ün 104 M konsantrasyonda, a-tokoferol ile karşılaştırıldıklarında erkek karaciğer mikrozomal LP düzeylerinde belirgin bir azalmaya neden olduğu bulundu. Bileşiklerden 8 ve 10'ün. O/ anyonunu belirgin bir biçimde inhibe ettiği bulundu. Her iki aktivite sonucu, bu bileşiklerin ümit verici antioksidanlar olabileceklerini gösterdi.

N-sübstitüe indol-2 ve 3-karboksamitlerin antioksidan aktivitesi

A series of N-substituted indole amide derivatives was tested for in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) and superoxide anion (SOD) formation. Vitamin E (a-tocopherol) decreased the LP level by about 63% at 104 M concentration. A significant decrease in male liver microsomal LP level was noted for the compounds 1, 8 and W at a concentration of 10'4M comparing with a-tocopherol. The inhibition of O2(~ by compounds 8 and 10 were found highly efficient. Both activity results show that these compounds are promising antioxidants.

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