Muhammet OKTAY, Gülseren OKTAY, Yusuf ERTEKİN, Cemil SÖNMEZ, Feruze SÖNMEZ

Yeni Tespit Tip 2 Diyabetik Hastalarda Metabolik Sendrom Sıklığı ve Bileşenlerinin Değerlendirilmesi

Amaç:Çalışmayı yeni tespit edilen veya hiç tedavi almamış tip 2 diyabetik hastalarda metabolik sendrom ve bileşenlerinin sıklığını ve ilişkisini belirleyebilmek amacıyla planladık.Metod: Çalışmaya alınan 220 diyabetik hastanın kilo, boy, bel çevresi, vücut kitle indeksi, açlık kan şekeri, tansiyon, HbA1c, total kolesterol, trigliserid, LDL, HDL verilerine ek olarak birinci derece akrabalarında, metabolik sendrom bileşenleri sorgulandı.Sonuç: Yeni tespit edilen tip 2 diyabetik hastalarla yaptığımız çalışmamızda, Metabolik Sendrom(MS) sıklığını Ulusal Kolesterol Eğitim Programı(NCEP)’na göre %70,5, Uluslararası Diyabet Federasyonu (IDF)’na göre %80 olarak tespitedildi. Cinsiyete göre kadın ve erkekte MS olma oranları sırayla %84,8 ve %75,6 idi. Hastaların birinci derece akrabaları olan ebeveyn, kardeş ve çocukların tümünde MS bileşeni olarak obezite birinci sırada yer aldı.Tartışma: İnsülin direncini en iyi yansıtan kriterin yine bel çevresi olduğu görüldü. NCEP’in kriterlerine göre MS olan ile olmayan hastaların AKŞ değerlerinde anlamlı bir farklılık saptanmamasının sebebi olarak NCEP’nin uzun dönemde riski azaltmak için AKŞ’nin eşik değerini düşük tuttuğu düşünüldü. Diyabetli hastaların anne, baba, kardeş ve çocuklarında obezitenin birinci sırada ve sıklıkla yer alması, obezitenin diyabet ve insülin direnci ile ortak genlerden aktarılabilecek bir hastalık olabileceği şüphesini uyandırdı.

Anahtar Kelimeler:

Diyabet, insülin direnci, metabolik sendrom, obezite

The Evaluation Of Metabolic Syndrome Frequency And Its Components In Newly Diagnosed Type-2 Diabetic Patients

Purpose: We planned this study in order to identify the relationship between metabolic syndrome and its components and the frequency of it in untreated type- 2 DM patients and in patients with new diagnosis type 2- DM. Methods: In the study, 220 diabetic patients were questioned on weight, height, waist circumference, body mass index, fasting blood glucose, blood pressure, HbA1c, total cholesterol, triglycerides, LDL, HDL data, in addition to the components of metabolic syndrome in first-degree relatives. Results: In our study on new diagnosed type-2 diabetic patients, the frequency of metabolic syndrome (MS) was found 70.5%,according to National Cholesterol Education Program (NCEP), and 80% according to the International Diabetes Federation (IDF) . The rates of MS by gender in women and men was 84.8% and 75.6%, respectively. Obesity was found as the most frequent MS component in all the first-degree relatives of the patients; parents, sisters, brothers and children . Discussion: Waist circumference was found to be the best reflecting criteria of insulin resistance. According to the NCEP criteria, no significant difference was found in fasting blood glucose levels in MS and non MS patients. The reason for this was thought to be the fact that NCEP kept fasting blood glucose threshold value low, in order to reduce the long-term risks. The entity that obesity was found in all the first-degree relatives of the diabetic patients aroused the suspicion that obesity disease may be transferred with the same genes with diabetes and insulin resistance.

Keywords:

Diabetes, insulin resistance, metabolic syndrome, obesity,

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