Habibe HEZER, Ayşegül KARALEZLİ, Emine ARGÜDER, H. Canan HASANOĞLU, Hatice KİLİC, Funda KARADUMAN YALCİN, Cantürk KAYA, Tuba ÖĞÜT

ORTALAMA TROMBOSİT HACMİ (MPV) KOAH’LI HASTALARDA KARDİYOVASKÜLER HASTALIKLARIN DEĞERLENDİRİLMESİNDE ÖNEMLİ MİDİR?

Amaç: Ortalama trombosit hacmi (MPV) trombosit aktivasyonunun bir indeksidir. Bu çalışmada, göğüs hastalıkları bölümüne başvuran KOAH ve kardiyovasküler hastalık olan hastalar ile MPV arasındaki ilişkiyi değerlendirmeyi amaçladık. Materyal ve Metot: Sigara içen 535 (%71,80) ve sigara içmeyen, 210 (%28,20) hasta MPV ve diğer parametrelerle karşılaştırıldı. Bulgular: Sigara içenlerde beyaz kan hücrelerinin (Wbc), hemoglobin (Hgb) ve Hematokrit (Htc) düzeyleri sigara içmeyenlere göre istatistiksel olarak anlamlı derecede yüksekti (p

DOES THE MEAN PLATELET VOLUME (MPV) HAVE ANY IMPORTANCE IN THE EVALUATION OF CARDIOVASCULAR DISEASE IN COPD PATIENTS?

Objectives: : Mean platelet volume (MPV) is an index of platelet activation. In this study, we aimed to evaluate the relationship between in patients with COPD and cardiovasculary disease who present to chest diseases department and MPV.Materials and Methods: Smoker 535 (71.80%) and non-smoker, 210 (28.20%) subjects were compared for MPV and other parameters. Accordingly, patients with and without COPD were compared in terms of MPV and other parameters.Results: The levels of white blood cells (Wbc), hemoglobin (Hgb) and hematocrit (Htc) in smokers were statistically significantly higher than non-smokers (p

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1. From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2010. Definition: Chapter 1;1-7.
2. Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009;33:1165- 85.
3. Vernooy JH, Küçükaycan M, Jacobs JA et all. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Am J Respir Crit Care Med 2002;166:1218-24.
4. Dev D, Wallace E, Sankaran R et all. Value of C‐reactive protein measurements in exacerbations of chronic obstructive pulmonary disease. Respir Med 1998;92:664-7.
5. Schols AM, Buurman WA, Staal van den Brekel AJ, Dentener MA, Wouters EF. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996;51:819-24.
6. Kapsoritakis AN, Koukourakis MI, Sfiridaki A et all. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776-81.
7. Milovanovic M, Nilsson E, Järemo P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta 2004;343:237-40.
8. Yazici S, Yazici M, Erer B et all. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 2010;21:122-5.
9. Kisacik B, Tufan A, Kalyoncu U et all. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291-4.
10. Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn 2012;122(6):284-90.
11. Wang, R.-t.,Li, J.-Y., Cao, Z.-g. and Li, Y. Mean platelet volume is decreased during an acute exacerbation of chronic obstructive pulmonary disease. Respirology 2013;18(8):1244–8.
12. Thompson CB, Jacubowski JA, Quinn PG, Deykin D, Valeri CR. Platelet size is a determinant of platelet function. J Lab Clin Med 1983;101:205–13.
13. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157–61.
14. Kilciler G, Genc H, Tapan S, et all. Mean platelet volume and its relationship with carotid atherosclerosis in subjects with nonalcoholic fatty liver disease. Ups J Med Sci 2010;115:253–9.
15. Coban E, Yazicioglu G, Berkant Avci A, Akcit F. The mean platelet volume in patients with essential and white coat hypertension. Platelets 2005;16:435–8.
16. Peker Y, Hedner J, Kraiczi H, Lo th S. Respiratory disturbance index: an independent predictor of mortality in coronary artery disease. Am J Respir Crit Care Med 2000;162:81–6.
17. Dyken ME, Somers VK, Yamada T, Ren ZY, Zimmerman MB. Investigating the relationship between stroke and obstructive sleep apnea. Stroke 1996;27:401–40.
18. Köksal D, Seğmen F, Koyuncu A, Atasever M, Berkoğlu M. Mean Platelet Volume: Is there a Link Between Stage and Venous Thrombosis in Non-Small Cell Lung Cancer? Solunum Hastalıkları 2013;24(2):53–7.
19. Ermis H, Yucel N, Gulbas G, Turkkan S, Aytemur ZA. Does the mean platelet volume have any importance in patients with acute pulmonary embolism? Wien Klin Wochenschr 2013;125 (14):381.
20. Ozsu S, Abul Y, Gunaydin S, Orem A and Ozlu T. Prognostic Value of Red Cell Distribution Width in Patients With Pulmonary Embolism. Clinical and Applied Thrombosis/Hemostasis 2012;1-6.
21. Steiropoulos P, Papanas N, Nena E et all. Mean Platelet Volume and Platelet Distribution Width in Patients With Chronic Obstructive Pulmonary Disease. The Role of Comorbidities. Angiology 2013; 64 (7):535-9.
22. Erikçi AA, Terekeci H, Ulusoy RE, Öztürk A. Sigara içen Genç Erkeklerde Trombosit Parametreleri. Bakırköy Tıp Dergisi 2009;5:22-4.
23. Kostrubiec M, Łabyk A, Pedowska-Włoszek J et all. Mean platelet volüme predicts early death in acute pulmonary embolism. Heart 2010;96:460–5.
24. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets 2002;13:301–6.
25. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28– 32.
26. Günay E, Ulasli SS, Kacar E et al. Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism? The Clinical Respiratory Journal 2013;1-8.